Perineurial abnormalities in the spontaneously diabetic dog

M. Ghani, Rayaz Malik, D. Walker, A. K. Sharma, C. T. Lowrie, W. D. Schall, A. J M Boulton

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Structural abnormalities of the perineurium from six spontaneously diabetic dogs (diabetes duration 4-8 years and six control animals were quantified using detailed electron microscopic morphometric methods on superficial peroneal nerve biopsy specimens. Total perineurial sheath thickness (μm) was significantly increased in diabetic (8.8 ± 0.6) compared to control animals (6.2 ± 0.3) (P < 0.02). This was attributed to a significant increase in the mean perineurial lamellar width in diabetic (0.49 ± 0.03) compared to control (0.40 ± 0.01) (P < 0.04) animals. The number of lamellae also showed a non-significant increase in diabetic animals (7.8 ± 0.4) compared to controls (6.9 ± 0.13) (P < 0.06). There was no change in the mean interlamellar space in diabetic (0.7 ± 0.05) compared to control (0.6 ± 0.06) (P = 0.15) animals. The total interlamellar space was increased in diabetic (5.7 ± 0.5) compared to control(4.1 ± 0.36) (P < 0.04) animals. The perineurial cell basement membrane thickness (nm) was significantly increased in diabetic (126.9 ± 9.8) compared to control (62.8 ± 6.1) (P < 0.005) animals. The current study has demonstrated significant abnormalities of the perineurium in the spontaneously diabetic dog, which may have relevance to the pathogenesis of diabetic neuropathy.

Original languageEnglish
Pages (from-to)98-102
Number of pages5
JournalActa Neuropathologica
Volume97
Issue number1
DOIs
Publication statusPublished - Jan 1999
Externally publishedYes

Fingerprint

Dogs
Peripheral Nerves
Peroneal Nerve
Diabetic Neuropathies
Basement Membrane
Cell Membrane
Electrons
Biopsy

Keywords

  • Morphometry
  • Perineurium
  • Peripheral neuropathy
  • Spontaneous diabetes

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Ghani, M., Malik, R., Walker, D., Sharma, A. K., Lowrie, C. T., Schall, W. D., & Boulton, A. J. M. (1999). Perineurial abnormalities in the spontaneously diabetic dog. Acta Neuropathologica, 97(1), 98-102. https://doi.org/10.1007/s004010050961

Perineurial abnormalities in the spontaneously diabetic dog. / Ghani, M.; Malik, Rayaz; Walker, D.; Sharma, A. K.; Lowrie, C. T.; Schall, W. D.; Boulton, A. J M.

In: Acta Neuropathologica, Vol. 97, No. 1, 01.1999, p. 98-102.

Research output: Contribution to journalArticle

Ghani, M, Malik, R, Walker, D, Sharma, AK, Lowrie, CT, Schall, WD & Boulton, AJM 1999, 'Perineurial abnormalities in the spontaneously diabetic dog', Acta Neuropathologica, vol. 97, no. 1, pp. 98-102. https://doi.org/10.1007/s004010050961
Ghani M, Malik R, Walker D, Sharma AK, Lowrie CT, Schall WD et al. Perineurial abnormalities in the spontaneously diabetic dog. Acta Neuropathologica. 1999 Jan;97(1):98-102. https://doi.org/10.1007/s004010050961
Ghani, M. ; Malik, Rayaz ; Walker, D. ; Sharma, A. K. ; Lowrie, C. T. ; Schall, W. D. ; Boulton, A. J M. / Perineurial abnormalities in the spontaneously diabetic dog. In: Acta Neuropathologica. 1999 ; Vol. 97, No. 1. pp. 98-102.
@article{3f5d7bee7dee4c36b5415252971f9b18,
title = "Perineurial abnormalities in the spontaneously diabetic dog",
abstract = "Structural abnormalities of the perineurium from six spontaneously diabetic dogs (diabetes duration 4-8 years and six control animals were quantified using detailed electron microscopic morphometric methods on superficial peroneal nerve biopsy specimens. Total perineurial sheath thickness (μm) was significantly increased in diabetic (8.8 ± 0.6) compared to control animals (6.2 ± 0.3) (P < 0.02). This was attributed to a significant increase in the mean perineurial lamellar width in diabetic (0.49 ± 0.03) compared to control (0.40 ± 0.01) (P < 0.04) animals. The number of lamellae also showed a non-significant increase in diabetic animals (7.8 ± 0.4) compared to controls (6.9 ± 0.13) (P < 0.06). There was no change in the mean interlamellar space in diabetic (0.7 ± 0.05) compared to control (0.6 ± 0.06) (P = 0.15) animals. The total interlamellar space was increased in diabetic (5.7 ± 0.5) compared to control(4.1 ± 0.36) (P < 0.04) animals. The perineurial cell basement membrane thickness (nm) was significantly increased in diabetic (126.9 ± 9.8) compared to control (62.8 ± 6.1) (P < 0.005) animals. The current study has demonstrated significant abnormalities of the perineurium in the spontaneously diabetic dog, which may have relevance to the pathogenesis of diabetic neuropathy.",
keywords = "Morphometry, Perineurium, Peripheral neuropathy, Spontaneous diabetes",
author = "M. Ghani and Rayaz Malik and D. Walker and Sharma, {A. K.} and Lowrie, {C. T.} and Schall, {W. D.} and Boulton, {A. J M}",
year = "1999",
month = "1",
doi = "10.1007/s004010050961",
language = "English",
volume = "97",
pages = "98--102",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Perineurial abnormalities in the spontaneously diabetic dog

AU - Ghani, M.

AU - Malik, Rayaz

AU - Walker, D.

AU - Sharma, A. K.

AU - Lowrie, C. T.

AU - Schall, W. D.

AU - Boulton, A. J M

PY - 1999/1

Y1 - 1999/1

N2 - Structural abnormalities of the perineurium from six spontaneously diabetic dogs (diabetes duration 4-8 years and six control animals were quantified using detailed electron microscopic morphometric methods on superficial peroneal nerve biopsy specimens. Total perineurial sheath thickness (μm) was significantly increased in diabetic (8.8 ± 0.6) compared to control animals (6.2 ± 0.3) (P < 0.02). This was attributed to a significant increase in the mean perineurial lamellar width in diabetic (0.49 ± 0.03) compared to control (0.40 ± 0.01) (P < 0.04) animals. The number of lamellae also showed a non-significant increase in diabetic animals (7.8 ± 0.4) compared to controls (6.9 ± 0.13) (P < 0.06). There was no change in the mean interlamellar space in diabetic (0.7 ± 0.05) compared to control (0.6 ± 0.06) (P = 0.15) animals. The total interlamellar space was increased in diabetic (5.7 ± 0.5) compared to control(4.1 ± 0.36) (P < 0.04) animals. The perineurial cell basement membrane thickness (nm) was significantly increased in diabetic (126.9 ± 9.8) compared to control (62.8 ± 6.1) (P < 0.005) animals. The current study has demonstrated significant abnormalities of the perineurium in the spontaneously diabetic dog, which may have relevance to the pathogenesis of diabetic neuropathy.

AB - Structural abnormalities of the perineurium from six spontaneously diabetic dogs (diabetes duration 4-8 years and six control animals were quantified using detailed electron microscopic morphometric methods on superficial peroneal nerve biopsy specimens. Total perineurial sheath thickness (μm) was significantly increased in diabetic (8.8 ± 0.6) compared to control animals (6.2 ± 0.3) (P < 0.02). This was attributed to a significant increase in the mean perineurial lamellar width in diabetic (0.49 ± 0.03) compared to control (0.40 ± 0.01) (P < 0.04) animals. The number of lamellae also showed a non-significant increase in diabetic animals (7.8 ± 0.4) compared to controls (6.9 ± 0.13) (P < 0.06). There was no change in the mean interlamellar space in diabetic (0.7 ± 0.05) compared to control (0.6 ± 0.06) (P = 0.15) animals. The total interlamellar space was increased in diabetic (5.7 ± 0.5) compared to control(4.1 ± 0.36) (P < 0.04) animals. The perineurial cell basement membrane thickness (nm) was significantly increased in diabetic (126.9 ± 9.8) compared to control (62.8 ± 6.1) (P < 0.005) animals. The current study has demonstrated significant abnormalities of the perineurium in the spontaneously diabetic dog, which may have relevance to the pathogenesis of diabetic neuropathy.

KW - Morphometry

KW - Perineurium

KW - Peripheral neuropathy

KW - Spontaneous diabetes

UR - http://www.scopus.com/inward/record.url?scp=0033067774&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033067774&partnerID=8YFLogxK

U2 - 10.1007/s004010050961

DO - 10.1007/s004010050961

M3 - Article

VL - 97

SP - 98

EP - 102

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 1

ER -