Performance of a microfluidic device for in situ ToF-SIMS analysis of selected organic molecules at aqueous surfaces

Li Yang, Zihua Zhu, Xiao Ying Yu, Suntharampillai Thevuthasan, James P. Cowin

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    Abstract

    In this study, we report new results concerning the analytical performance of a novel portable vacuum compatible device enabling in situ study of aqueous surfaces using vacuum-based surface analysis tools. The surfaces of aqueous solutions of three representative organic molecules (formic acid, glycerol, and glutamic acid) were analyzed using time-of-flight secondary ion mass spectrometry (ToF-SIMS). Their molecular signals were successfully observed. The device can be operated without interruption in vacuum for up to 8 hours, and SIMS measurements are feasible at any time in this time range. The stability testing of our device under primary ion beam bombardment shows that high fluence (6 × 1012 ions per cm2 s-1) measurements can be operated continuously for up to 30 minutes without any significant damage to the aperture. However, extra-high fluence measurements (>1 × 1014 ions per cm2 s-1) may lead to rapid boiling in the aperture, and the aqueous solutions may spread out quickly. Device reproducibility is studied for both consecutive measurements over a short period of time (e.g., 5 min) and intermittent measurements over a long time (e.g., several hours). The relative standard deviation (RSD) for molecular ion signals was determined to be less than 15% for consecutive measurements in 5 min. As to total counts, the RSD is determined to be less than 1% for each chemical compound. Higher RSDs of ±40-50% were obtained for intermittent measurements in a few hours, both acceptable for semi-quantitative analysis. In addition, the detection limits of formic acid, glycerol, and glutamic acid are estimated to be 0.04%, 0.008%, and 0.002% (weight ratio), respectively.

    Original languageEnglish
    Pages (from-to)2515-2522
    Number of pages8
    JournalAnalytical Methods
    Volume5
    Issue number10
    DOIs
    Publication statusPublished - 21 May 2013

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    ASJC Scopus subject areas

    • Analytical Chemistry
    • Chemical Engineering(all)
    • Engineering(all)

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