Peptide-based vaccines for cancer therapy

Giorgio Parmiani, Vincenzo Russo, Cristina Maccalli, Danilo Parolini, Nathalie Rizzo, Michele Maio

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Interest for cancer vaccination started more than 30 years ago after the demonstration that both in animal models and later on in patients it is possible to generate anti-tumor immune responses. The clinical application of this knowledge, however, was disappointing. In this review we summarize results on peptides epitopes recognized by T cells that have been studied thanks to their easy synthesis and the lack of significant side effects when administered in-vivo. To improve the clinical efficacy, peptides were modified in their aminoacid sequence to augment their immunogenicity. Peptides vaccines were recently shown to induce a high frequency of immune response in patients that were accompanied by clinical efficacy. These data are discussed at the light of recent progression of immunotherapy caused by the addition of check-point antibodies thus providing a general picture of the potential therapeutic efficacy of the peptide-based vaccines and their combination with other biological agents.

Original languageEnglish
Pages (from-to)3175-3178
Number of pages4
JournalHuman Vaccines and Immunotherapeutics
Volume10
Issue number11
DOIs
Publication statusPublished - 1 Nov 2014
Externally publishedYes

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Keywords

  • Antigens
  • Cancer
  • Epitopes
  • Immune responses
  • Vaccination

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Parmiani, G., Russo, V., Maccalli, C., Parolini, D., Rizzo, N., & Maio, M. (2014). Peptide-based vaccines for cancer therapy. Human Vaccines and Immunotherapeutics, 10(11), 3175-3178. https://doi.org/10.4161/hv.29418