PEGylated inorganic nanoparticles

Ajay S. Karakoti, Soumen Das, Suntharampillai Thevuthasan, Sudipta Seal

Research output: Contribution to journalArticle

346 Citations (Scopus)

Abstract

Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long-term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides "stealth" characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure-directing agent in synthesis of oxides is also presented.

Original languageEnglish
Pages (from-to)1980-1994
Number of pages15
JournalAngewandte Chemie - International Edition
Volume50
Issue number9
DOIs
Publication statusPublished - 25 Feb 2011
Externally publishedYes

    Fingerprint

Keywords

  • metal oxides
  • nanoparticles
  • nanotherapeutics
  • PEGylation
  • surface modification

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Karakoti, A. S., Das, S., Thevuthasan, S., & Seal, S. (2011). PEGylated inorganic nanoparticles. Angewandte Chemie - International Edition, 50(9), 1980-1994. https://doi.org/10.1002/anie.201002969