PEGylated inorganic nanoparticles

Ajay S. Karakoti, Soumen Das, Suntharampillai Thevuthasan, Sudipta Seal

Research output: Contribution to journalArticle

336 Citations (Scopus)

Abstract

Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long-term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides "stealth" characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure-directing agent in synthesis of oxides is also presented.

Original languageEnglish
Pages (from-to)1980-1994
Number of pages15
JournalAngewandte Chemie - International Edition
Volume50
Issue number9
DOIs
Publication statusPublished - 25 Feb 2011
Externally publishedYes

Fingerprint

Nanoparticles
Oxides
Polyethylene glycols
Surface treatment
Nanostructures
Human Body
Nanostructured materials
Solubility
Functional groups
Therapeutics

Keywords

  • metal oxides
  • nanoparticles
  • nanotherapeutics
  • PEGylation
  • surface modification

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Karakoti, A. S., Das, S., Thevuthasan, S., & Seal, S. (2011). PEGylated inorganic nanoparticles. Angewandte Chemie - International Edition, 50(9), 1980-1994. https://doi.org/10.1002/anie.201002969

PEGylated inorganic nanoparticles. / Karakoti, Ajay S.; Das, Soumen; Thevuthasan, Suntharampillai; Seal, Sudipta.

In: Angewandte Chemie - International Edition, Vol. 50, No. 9, 25.02.2011, p. 1980-1994.

Research output: Contribution to journalArticle

Karakoti, AS, Das, S, Thevuthasan, S & Seal, S 2011, 'PEGylated inorganic nanoparticles', Angewandte Chemie - International Edition, vol. 50, no. 9, pp. 1980-1994. https://doi.org/10.1002/anie.201002969
Karakoti AS, Das S, Thevuthasan S, Seal S. PEGylated inorganic nanoparticles. Angewandte Chemie - International Edition. 2011 Feb 25;50(9):1980-1994. https://doi.org/10.1002/anie.201002969
Karakoti, Ajay S. ; Das, Soumen ; Thevuthasan, Suntharampillai ; Seal, Sudipta. / PEGylated inorganic nanoparticles. In: Angewandte Chemie - International Edition. 2011 ; Vol. 50, No. 9. pp. 1980-1994.
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