Abstract
Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long-term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides "stealth" characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure-directing agent in synthesis of oxides is also presented.
| Original language | English |
|---|---|
| Pages (from-to) | 1980-1994 |
| Number of pages | 15 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 50 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 25 Feb 2011 |
| Externally published | Yes |
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Keywords
- metal oxides
- nanoparticles
- nanotherapeutics
- PEGylation
- surface modification
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
Cite this
PEGylated inorganic nanoparticles. / Karakoti, Ajay S.; Das, Soumen; Thevuthasan, Suntharampillai; Seal, Sudipta.
In: Angewandte Chemie - International Edition, Vol. 50, No. 9, 25.02.2011, p. 1980-1994.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - PEGylated inorganic nanoparticles
AU - Karakoti, Ajay S.
AU - Das, Soumen
AU - Thevuthasan, Suntharampillai
AU - Seal, Sudipta
PY - 2011/2/25
Y1 - 2011/2/25
N2 - Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long-term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides "stealth" characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure-directing agent in synthesis of oxides is also presented.
AB - Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long-term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides "stealth" characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure-directing agent in synthesis of oxides is also presented.
KW - metal oxides
KW - nanoparticles
KW - nanotherapeutics
KW - PEGylation
KW - surface modification
UR - http://www.scopus.com/inward/record.url?scp=79951861958&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951861958&partnerID=8YFLogxK
U2 - 10.1002/anie.201002969
DO - 10.1002/anie.201002969
M3 - Article
VL - 50
SP - 1980
EP - 1994
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 9
ER -