PAZ6 cells constitute a representative model for human brown pre-adipocytes

Melissa Kazantzis, Virginia Takahashi, Jessica Hinkle, Smitha Kota, Vladimir Zilberfarb, Tarik Issad, Mouaadh Abdelkarim, Lotfi Chouchane, Arthur Donny Strosberg

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The role of brown adipose tissue (BAT) in human metabolism and its potential as an anti-obesity target organ have recently received much renewed attention. Following radiological detection of substantial amounts of BAT in adults by several independent research groups, an increasing number of studies are now dedicated to uncover BAT's genetic, developmental, and environmental determinants. In contrast to murine BAT, human BAT is not present as a single major fat depot in a well-defined location. The distribution of BAT in several areas in the body significantly limits its availability to research. A human brown adipocyte cell line is therefore critical in broadening the options available to researchers in the field. The human BAT-cell line PAZ6 was created to address such a need and has been well characterized by several research groups around the world. In the present review, we discuss their findings and propose potential applications of the PAZ6 cells in addressing the relevant questions in the BAT field, namely for future use in therapeutic applications.

Original languageEnglish
Article numberArticle 13
JournalFrontiers in Endocrinology
Volume3
Issue numberFEB
DOIs
Publication statusPublished - 2012

Fingerprint

Brown Adipocytes
Brown Adipose Tissue
Research
Cell Line
Therapeutic Uses
Obesity
Fats
Research Personnel

Keywords

  • Brown adipocytes
  • Cell lines
  • Obesity
  • PAZ6 cells

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Kazantzis, M., Takahashi, V., Hinkle, J., Kota, S., Zilberfarb, V., Issad, T., ... Strosberg, A. D. (2012). PAZ6 cells constitute a representative model for human brown pre-adipocytes. Frontiers in Endocrinology, 3(FEB), [Article 13]. https://doi.org/10.3389/fendo.2012.00013

PAZ6 cells constitute a representative model for human brown pre-adipocytes. / Kazantzis, Melissa; Takahashi, Virginia; Hinkle, Jessica; Kota, Smitha; Zilberfarb, Vladimir; Issad, Tarik; Abdelkarim, Mouaadh; Chouchane, Lotfi; Strosberg, Arthur Donny.

In: Frontiers in Endocrinology, Vol. 3, No. FEB, Article 13, 2012.

Research output: Contribution to journalReview article

Kazantzis, M, Takahashi, V, Hinkle, J, Kota, S, Zilberfarb, V, Issad, T, Abdelkarim, M, Chouchane, L & Strosberg, AD 2012, 'PAZ6 cells constitute a representative model for human brown pre-adipocytes', Frontiers in Endocrinology, vol. 3, no. FEB, Article 13. https://doi.org/10.3389/fendo.2012.00013
Kazantzis M, Takahashi V, Hinkle J, Kota S, Zilberfarb V, Issad T et al. PAZ6 cells constitute a representative model for human brown pre-adipocytes. Frontiers in Endocrinology. 2012;3(FEB). Article 13. https://doi.org/10.3389/fendo.2012.00013
Kazantzis, Melissa ; Takahashi, Virginia ; Hinkle, Jessica ; Kota, Smitha ; Zilberfarb, Vladimir ; Issad, Tarik ; Abdelkarim, Mouaadh ; Chouchane, Lotfi ; Strosberg, Arthur Donny. / PAZ6 cells constitute a representative model for human brown pre-adipocytes. In: Frontiers in Endocrinology. 2012 ; Vol. 3, No. FEB.
@article{3b459cb289fe4d5e87e92db6cf7cf445,
title = "PAZ6 cells constitute a representative model for human brown pre-adipocytes",
abstract = "The role of brown adipose tissue (BAT) in human metabolism and its potential as an anti-obesity target organ have recently received much renewed attention. Following radiological detection of substantial amounts of BAT in adults by several independent research groups, an increasing number of studies are now dedicated to uncover BAT's genetic, developmental, and environmental determinants. In contrast to murine BAT, human BAT is not present as a single major fat depot in a well-defined location. The distribution of BAT in several areas in the body significantly limits its availability to research. A human brown adipocyte cell line is therefore critical in broadening the options available to researchers in the field. The human BAT-cell line PAZ6 was created to address such a need and has been well characterized by several research groups around the world. In the present review, we discuss their findings and propose potential applications of the PAZ6 cells in addressing the relevant questions in the BAT field, namely for future use in therapeutic applications.",
keywords = "Brown adipocytes, Cell lines, Obesity, PAZ6 cells",
author = "Melissa Kazantzis and Virginia Takahashi and Jessica Hinkle and Smitha Kota and Vladimir Zilberfarb and Tarik Issad and Mouaadh Abdelkarim and Lotfi Chouchane and Strosberg, {Arthur Donny}",
year = "2012",
doi = "10.3389/fendo.2012.00013",
language = "English",
volume = "3",
journal = "Frontiers in Endocrinology",
issn = "1664-2392",
publisher = "Frontiers Media S. A.",
number = "FEB",

}

TY - JOUR

T1 - PAZ6 cells constitute a representative model for human brown pre-adipocytes

AU - Kazantzis, Melissa

AU - Takahashi, Virginia

AU - Hinkle, Jessica

AU - Kota, Smitha

AU - Zilberfarb, Vladimir

AU - Issad, Tarik

AU - Abdelkarim, Mouaadh

AU - Chouchane, Lotfi

AU - Strosberg, Arthur Donny

PY - 2012

Y1 - 2012

N2 - The role of brown adipose tissue (BAT) in human metabolism and its potential as an anti-obesity target organ have recently received much renewed attention. Following radiological detection of substantial amounts of BAT in adults by several independent research groups, an increasing number of studies are now dedicated to uncover BAT's genetic, developmental, and environmental determinants. In contrast to murine BAT, human BAT is not present as a single major fat depot in a well-defined location. The distribution of BAT in several areas in the body significantly limits its availability to research. A human brown adipocyte cell line is therefore critical in broadening the options available to researchers in the field. The human BAT-cell line PAZ6 was created to address such a need and has been well characterized by several research groups around the world. In the present review, we discuss their findings and propose potential applications of the PAZ6 cells in addressing the relevant questions in the BAT field, namely for future use in therapeutic applications.

AB - The role of brown adipose tissue (BAT) in human metabolism and its potential as an anti-obesity target organ have recently received much renewed attention. Following radiological detection of substantial amounts of BAT in adults by several independent research groups, an increasing number of studies are now dedicated to uncover BAT's genetic, developmental, and environmental determinants. In contrast to murine BAT, human BAT is not present as a single major fat depot in a well-defined location. The distribution of BAT in several areas in the body significantly limits its availability to research. A human brown adipocyte cell line is therefore critical in broadening the options available to researchers in the field. The human BAT-cell line PAZ6 was created to address such a need and has been well characterized by several research groups around the world. In the present review, we discuss their findings and propose potential applications of the PAZ6 cells in addressing the relevant questions in the BAT field, namely for future use in therapeutic applications.

KW - Brown adipocytes

KW - Cell lines

KW - Obesity

KW - PAZ6 cells

UR - http://www.scopus.com/inward/record.url?scp=84874423196&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874423196&partnerID=8YFLogxK

U2 - 10.3389/fendo.2012.00013

DO - 10.3389/fendo.2012.00013

M3 - Review article

VL - 3

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

SN - 1664-2392

IS - FEB

M1 - Article 13

ER -