Pathology of human diabetic neuropathy

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Pathologic study of a disease provides insights into the precise mechanisms and targets of damage and may provide insights into new therapies. The main targets in diabetic neuropathy are myelinated and unmyelinated fibers as dysfunction and damage to them explains the symptoms of painful neuropathy and the major end points of foot ulceration and amputation as well as mortality. Demyelination and axonal degeneration are established hallmarks of the pathology of human diabetic neuropathy and were derived from pioneering light and electronmicroscopic studies of sural nerve biopsies in the late 1960s and early 1970s. Additional abnormalities, which are relevant to the pathogenesis of human diabetic neuropathy, include pathology of the microvessels and extracellular space. Intraepidermal and sudomotor nerve quantification in skin biopsies provides a minimally invasive means for the detection of early nerve damage. Studies of muscle biopsies are limited and show significant alterations in the expression of neurotrophins, but limited changes in muscle fiber size and capillary density.

Original languageEnglish
Pages (from-to)249-259
Number of pages11
JournalHandbook of Clinical Neurology
Volume126
DOIs
Publication statusPublished - 2014

Fingerprint

Diabetic Neuropathies
Pathology
Biopsy
Muscles
Sural Nerve
Nerve Growth Factors
Extracellular Space
Demyelinating Diseases
Microvessels
Amputation
Foot
Light
Skin
Mortality
Therapeutics

Keywords

  • Diabetic neuropathy
  • Endoneurial capillaries
  • Muscle biopsy
  • Myelinated fibers
  • Nerve biopsy
  • Skin biopsy
  • Unmyelinated fibers

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Medicine(all)

Cite this

Pathology of human diabetic neuropathy. / Malik, Rayaz.

In: Handbook of Clinical Neurology, Vol. 126, 2014, p. 249-259.

Research output: Contribution to journalArticle

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