Pathogen recognition receptor crosstalk in respiratory syncytial virus sensing: A host and cell type perspective

Nico Marr, Stuart E. Turvey, Nathalie Grandvaux

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

Human respiratory syncytial virus (RSV) is a major cause of acute lower respiratory tract infection in young children, immunocompromised adults, and the elderly. The innate immune response plays a pivotal role in host defense against RSV, but whether severe outcomes following RSV infection result from excessive or poor innate immune recognition remains unclear. Recent research suggests a situation in which crosstalk between families of pattern recognition receptors (PRRs) occurs in a cell type-dependent manner. The current challenge to empower novel therapeutic approaches and vaccine development is to confirm the role of the individual receptors in RSV pathogenesis in humans.

Original languageEnglish
Pages (from-to)568-574
Number of pages7
JournalTrends in Microbiology
Volume21
Issue number11
DOIs
Publication statusPublished - Nov 2013
Externally publishedYes

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Keywords

  • Innate immunity
  • Pathogen recognition receptors
  • Pathogenesis
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

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