Parvovirus B19 infection in pediatric transplant patients

Bakr Nour, M. Green, M. Michaels, J. Reyes, A. Tzakis, J. C. Gartner, L. McLoughlin, T. E. Starzl

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Evidence of recent parvovirus virus infection (as determined by the presence of a positive IgM antibody titer) without other identified causes of anemia was found in 5 of 26 pediatric solid-organ transplant recipients evaluated for moderate-to-severe anemia between June 1990 and July 1991. Anemia tended to be chronic (median duration of anemia at the time of diagnosis was 12 weeks) and was associated with normal red blood cell indices in the absence of reticulocytes. The median age of the children at the time of presentation with anemia due to parvovirus was 1.8 years at a median time of 8 months after transplantation. Four of the 5 children were treated with i.v. immunoglobulin because of persistance of anemia requiring blood transfusions. A response characterized by an increase in reticulocyte count and normalization of hemoglobin was seen in each of these patients 2-4 weeks after treatment. The remaining patient experienced a spontaneous recovery from her anemia. Parvovirus infection should be included in the differential diagnosis of solid-organ transplant recipients presenting with severe anemia associated with low or absent reticulocytes.

Original languageEnglish
Pages (from-to)835-838
Number of pages4
JournalTransplantation
Volume56
Issue number4
Publication statusPublished - 1993
Externally publishedYes

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Parvoviridae Infections
Anemia
Pediatrics
Transplants
Reticulocytes
Reticulocyte Count
Parvovirus
Erythrocyte Indices
Virus Diseases
Blood Transfusion
Immunoglobulin M
Immunoglobulins
Hemoglobins
Differential Diagnosis
Transplantation
Erythrocytes
Antibodies

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Nour, B., Green, M., Michaels, M., Reyes, J., Tzakis, A., Gartner, J. C., ... Starzl, T. E. (1993). Parvovirus B19 infection in pediatric transplant patients. Transplantation, 56(4), 835-838.

Parvovirus B19 infection in pediatric transplant patients. / Nour, Bakr; Green, M.; Michaels, M.; Reyes, J.; Tzakis, A.; Gartner, J. C.; McLoughlin, L.; Starzl, T. E.

In: Transplantation, Vol. 56, No. 4, 1993, p. 835-838.

Research output: Contribution to journalArticle

Nour, B, Green, M, Michaels, M, Reyes, J, Tzakis, A, Gartner, JC, McLoughlin, L & Starzl, TE 1993, 'Parvovirus B19 infection in pediatric transplant patients', Transplantation, vol. 56, no. 4, pp. 835-838.
Nour B, Green M, Michaels M, Reyes J, Tzakis A, Gartner JC et al. Parvovirus B19 infection in pediatric transplant patients. Transplantation. 1993;56(4):835-838.
Nour, Bakr ; Green, M. ; Michaels, M. ; Reyes, J. ; Tzakis, A. ; Gartner, J. C. ; McLoughlin, L. ; Starzl, T. E. / Parvovirus B19 infection in pediatric transplant patients. In: Transplantation. 1993 ; Vol. 56, No. 4. pp. 835-838.
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