PARP1 Parylation Promotes Silent Locus Transmission in the Nucleolus: The Suspicion Confirmed

Maxim Isabelle, Imed Eddine Gallouzi, Guy G. Poirier

Research output: Contribution to journalShort survey

4 Citations (Scopus)


Parylation modulates various processes, including transcription. In this issue of Molecular Cell, Guetg et al. (2012) show that, in the nucleolus, PARP1-mediated parylation of TIP5 promotes the silencing of rDNA chromatin during replication, uncovering the mechanism by which PARP1 ensures that silent rDNA regions are properly inherited.

Original languageEnglish
Pages (from-to)706-707
Number of pages2
JournalMolecular Cell
Issue number6
Publication statusPublished - 30 Mar 2012


ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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