Parainfluenza and influenza virus infections in pediatric organ transplant recipients

Ann M. Apalsch, Michael Green, Jocyline Ledesma-Medina, Bakr Nour, Ellen R. Wald

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

We retrospectively reviewed parainfluenza and influenza virus infections that occurred in pediatric organ transplant recipients at our hospital from January 1985 through September 1992. Cultures of respiratory specimens revealed 45 infections in 42 transplant recipients (32 cases of parainfluenza and 13 cases of influenza virus infection). The following organs were transplanted: liver (28 patients), small bowel with and without liver (4), heart (3), lung with and without heart (5), and kidney (2). Clinical presentations of the patients and outcomes were similar regardless of the type of virus isolated or the type of organ transplanted. There were 20 cases in which patients had upper respiratory symptoms but did not require supplemental oxygen, nine cases in which patients required oxygen supplementation only, and eight cases in which patients survived with mechanical ventilation. Eight patients died (five had parainfluenza, three had influenza virus infection); four children had serious concurrent infections (cytomegaloviral pneumonia in one patient, bacteremia in two, bacteremia and pneumonia in one). Factors associated with poor outcome for the entire group were age (increased morbidity and mortality if < 6 months old), augmentation of immunosuppression, and onset of infection within 1 month after transplantation. In this patient population, parainfluenza and influenza infections were important causes of morbidity and mortality.

Original languageEnglish
Pages (from-to)394-399
Number of pages6
JournalClinical Infectious Diseases
Volume20
Issue number2
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Paramyxoviridae Infections
Orthomyxoviridae
Pediatrics
Transplants
Virus Diseases
Bacteremia
Infection
Pneumonia
Oxygen
Morbidity
Mortality
Transplant Recipients
Liver
Artificial Respiration
Immunosuppression
Human Influenza
Age Groups
Transplantation
Viruses
Kidney

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Immunology

Cite this

Parainfluenza and influenza virus infections in pediatric organ transplant recipients. / Apalsch, Ann M.; Green, Michael; Ledesma-Medina, Jocyline; Nour, Bakr; Wald, Ellen R.

In: Clinical Infectious Diseases, Vol. 20, No. 2, 1995, p. 394-399.

Research output: Contribution to journalArticle

Apalsch, Ann M. ; Green, Michael ; Ledesma-Medina, Jocyline ; Nour, Bakr ; Wald, Ellen R. / Parainfluenza and influenza virus infections in pediatric organ transplant recipients. In: Clinical Infectious Diseases. 1995 ; Vol. 20, No. 2. pp. 394-399.
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