Paradoxical arrest in lupus activity in BXSB mice with highly autoreactive T cells

M. Stojakovic, Zohreh Tatari Calderone, C. Maric, A. Hoang, S. Vukmanovic

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

T cells with high avidity for antigens are thought to mediate more effective immunity against foreign antigens and cause more severe autoimmunity. The impact of T cell receptor (TCR) avidity on the development of lupus has not been investigated. We took advantage of a transgenic mouse strain (designated MTB) that has a diverse T cell population and a globally stronger reactivity to self. [MTBxBXSB]F1 mice displayed accelerated lupus relative to the [WTxBXSB]F1 controls. The severity of lupus and the activation of T cells subsided with aging, when elevated IL-10 production by Tr1 cells was observed. Thus, chronic high avidity interactions of T cells with self-antigens can lead to an age associated increase in IL-10 production. This could explain the age-associated reduction of the incidence of lupus, as well as other autoimmune diseases. Furthermore, the principle of Tr1 differentiation based on diverse T cells with high avidity for self may potentially be used as a therapeutic strategy in the treatment of lupus. Lupus (2010) 19, 182-191.

Original languageEnglish
Pages (from-to)182-191
Number of pages10
JournalLupus
Volume19
Issue number2
DOIs
Publication statusPublished - Feb 2010
Externally publishedYes

Fingerprint

T-Lymphocytes
Interleukin-10
Antigens
Autoantigens
Regulatory T-Lymphocytes
T-Cell Antigen Receptor
Autoimmunity
Transgenic Mice
Autoimmune Diseases
Immunity
Incidence
Population
Therapeutics

Keywords

  • IL-10
  • Lupus
  • T cells
  • TCR avidity

ASJC Scopus subject areas

  • Rheumatology

Cite this

Paradoxical arrest in lupus activity in BXSB mice with highly autoreactive T cells. / Stojakovic, M.; Tatari Calderone, Zohreh; Maric, C.; Hoang, A.; Vukmanovic, S.

In: Lupus, Vol. 19, No. 2, 02.2010, p. 182-191.

Research output: Contribution to journalArticle

Stojakovic, M. ; Tatari Calderone, Zohreh ; Maric, C. ; Hoang, A. ; Vukmanovic, S. / Paradoxical arrest in lupus activity in BXSB mice with highly autoreactive T cells. In: Lupus. 2010 ; Vol. 19, No. 2. pp. 182-191.
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