PAI-1 in human hypertension: Relation to hypertensive groups

Nadarajah Srikumar, Nancy J. Brown, Paul N. Hopkins, Xavier Jeunemaitre, Steven Hunt, Douglas E. Vaughan, Gordon H. Williams

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Although the renin-angiotensin system and insulin resistance (IR) have been identified as major regulators of plasminogen activator inhibitor type-1 (PAI-1), their roles in hypertensive subjects is not clearly defined. Methods: We examined the effect of dietary salt restriction on PAI-1 levels in 239 hypertensive subjects from three centers. Subjects were placed on a 200 and 10 mmol/day sodium diets for 1-week periods. Plasma renin activity (PRA) and PAI-1 levels were measured on the last day of both diets and fasting insulin, glucose, and aldosterone (ALDO) levels, only on the low salt diet. Results: Sodium restriction increased PAI-1 levels from 32.1 ± 2.5 ng/mL to 39.8 ± 3.2 ng/mL (P = .009). There was a strong positive correlation between PAI-1 levels and PRA (r = 0.228, P = .0004), IR (r = 0.222, P = .001), triglycerides (r = 0.275, P < .001), and ALDO (P = .018 for linear trend). The patients were divided into low renin (low IR and ALDO levels), nonmodulators (normal PRA, high IR, and low ALDO levels), and modulators (normal PRA, intermediate IR, and normal ALDO levels) groups to assess the relative contribution of each factor to PAI-1 levels. Modulators had significantly (P = .019) higher PAI-1 levels compared to the low renin and nonmodulators who had similar PAI-1 levels. Conclusions: Plasma renin activity, IR, and ALDO all correlate with PAI-1 levels in the hypertensive subjects. However, the data suggest that ALDO may be an important factor contributing to the variability of PAI-1 levels in individual hypertensive subjects.

Original languageEnglish
Pages (from-to)683-690
Number of pages8
JournalAmerican Journal of Hypertension
Volume15
Issue number8
DOIs
Publication statusPublished - 2002
Externally publishedYes

Fingerprint

Plasminogen Activator Inhibitor 1
Aldosterone
Renin
Hypertension
Insulin Resistance
Sodium
Diet
Sodium-Restricted Diet
Renin-Angiotensin System
Fasting
Triglycerides
Salts
Insulin
Glucose

Keywords

  • Fibrinolysis
  • Hypertension
  • Renin-angiotensin system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Srikumar, N., Brown, N. J., Hopkins, P. N., Jeunemaitre, X., Hunt, S., Vaughan, D. E., & Williams, G. H. (2002). PAI-1 in human hypertension: Relation to hypertensive groups. American Journal of Hypertension, 15(8), 683-690. https://doi.org/10.1016/S0895-7061(02)02952-7

PAI-1 in human hypertension : Relation to hypertensive groups. / Srikumar, Nadarajah; Brown, Nancy J.; Hopkins, Paul N.; Jeunemaitre, Xavier; Hunt, Steven; Vaughan, Douglas E.; Williams, Gordon H.

In: American Journal of Hypertension, Vol. 15, No. 8, 2002, p. 683-690.

Research output: Contribution to journalArticle

Srikumar, N, Brown, NJ, Hopkins, PN, Jeunemaitre, X, Hunt, S, Vaughan, DE & Williams, GH 2002, 'PAI-1 in human hypertension: Relation to hypertensive groups', American Journal of Hypertension, vol. 15, no. 8, pp. 683-690. https://doi.org/10.1016/S0895-7061(02)02952-7
Srikumar, Nadarajah ; Brown, Nancy J. ; Hopkins, Paul N. ; Jeunemaitre, Xavier ; Hunt, Steven ; Vaughan, Douglas E. ; Williams, Gordon H. / PAI-1 in human hypertension : Relation to hypertensive groups. In: American Journal of Hypertension. 2002 ; Vol. 15, No. 8. pp. 683-690.
@article{4a6e244a50634e07b3fb2f965f515b3b,
title = "PAI-1 in human hypertension: Relation to hypertensive groups",
abstract = "Background: Although the renin-angiotensin system and insulin resistance (IR) have been identified as major regulators of plasminogen activator inhibitor type-1 (PAI-1), their roles in hypertensive subjects is not clearly defined. Methods: We examined the effect of dietary salt restriction on PAI-1 levels in 239 hypertensive subjects from three centers. Subjects were placed on a 200 and 10 mmol/day sodium diets for 1-week periods. Plasma renin activity (PRA) and PAI-1 levels were measured on the last day of both diets and fasting insulin, glucose, and aldosterone (ALDO) levels, only on the low salt diet. Results: Sodium restriction increased PAI-1 levels from 32.1 ± 2.5 ng/mL to 39.8 ± 3.2 ng/mL (P = .009). There was a strong positive correlation between PAI-1 levels and PRA (r = 0.228, P = .0004), IR (r = 0.222, P = .001), triglycerides (r = 0.275, P < .001), and ALDO (P = .018 for linear trend). The patients were divided into low renin (low IR and ALDO levels), nonmodulators (normal PRA, high IR, and low ALDO levels), and modulators (normal PRA, intermediate IR, and normal ALDO levels) groups to assess the relative contribution of each factor to PAI-1 levels. Modulators had significantly (P = .019) higher PAI-1 levels compared to the low renin and nonmodulators who had similar PAI-1 levels. Conclusions: Plasma renin activity, IR, and ALDO all correlate with PAI-1 levels in the hypertensive subjects. However, the data suggest that ALDO may be an important factor contributing to the variability of PAI-1 levels in individual hypertensive subjects.",
keywords = "Fibrinolysis, Hypertension, Renin-angiotensin system",
author = "Nadarajah Srikumar and Brown, {Nancy J.} and Hopkins, {Paul N.} and Xavier Jeunemaitre and Steven Hunt and Vaughan, {Douglas E.} and Williams, {Gordon H.}",
year = "2002",
doi = "10.1016/S0895-7061(02)02952-7",
language = "English",
volume = "15",
pages = "683--690",
journal = "American Journal of Hypertension",
issn = "0895-7061",
publisher = "Oxford University Press",
number = "8",

}

TY - JOUR

T1 - PAI-1 in human hypertension

T2 - Relation to hypertensive groups

AU - Srikumar, Nadarajah

AU - Brown, Nancy J.

AU - Hopkins, Paul N.

AU - Jeunemaitre, Xavier

AU - Hunt, Steven

AU - Vaughan, Douglas E.

AU - Williams, Gordon H.

PY - 2002

Y1 - 2002

N2 - Background: Although the renin-angiotensin system and insulin resistance (IR) have been identified as major regulators of plasminogen activator inhibitor type-1 (PAI-1), their roles in hypertensive subjects is not clearly defined. Methods: We examined the effect of dietary salt restriction on PAI-1 levels in 239 hypertensive subjects from three centers. Subjects were placed on a 200 and 10 mmol/day sodium diets for 1-week periods. Plasma renin activity (PRA) and PAI-1 levels were measured on the last day of both diets and fasting insulin, glucose, and aldosterone (ALDO) levels, only on the low salt diet. Results: Sodium restriction increased PAI-1 levels from 32.1 ± 2.5 ng/mL to 39.8 ± 3.2 ng/mL (P = .009). There was a strong positive correlation between PAI-1 levels and PRA (r = 0.228, P = .0004), IR (r = 0.222, P = .001), triglycerides (r = 0.275, P < .001), and ALDO (P = .018 for linear trend). The patients were divided into low renin (low IR and ALDO levels), nonmodulators (normal PRA, high IR, and low ALDO levels), and modulators (normal PRA, intermediate IR, and normal ALDO levels) groups to assess the relative contribution of each factor to PAI-1 levels. Modulators had significantly (P = .019) higher PAI-1 levels compared to the low renin and nonmodulators who had similar PAI-1 levels. Conclusions: Plasma renin activity, IR, and ALDO all correlate with PAI-1 levels in the hypertensive subjects. However, the data suggest that ALDO may be an important factor contributing to the variability of PAI-1 levels in individual hypertensive subjects.

AB - Background: Although the renin-angiotensin system and insulin resistance (IR) have been identified as major regulators of plasminogen activator inhibitor type-1 (PAI-1), their roles in hypertensive subjects is not clearly defined. Methods: We examined the effect of dietary salt restriction on PAI-1 levels in 239 hypertensive subjects from three centers. Subjects were placed on a 200 and 10 mmol/day sodium diets for 1-week periods. Plasma renin activity (PRA) and PAI-1 levels were measured on the last day of both diets and fasting insulin, glucose, and aldosterone (ALDO) levels, only on the low salt diet. Results: Sodium restriction increased PAI-1 levels from 32.1 ± 2.5 ng/mL to 39.8 ± 3.2 ng/mL (P = .009). There was a strong positive correlation between PAI-1 levels and PRA (r = 0.228, P = .0004), IR (r = 0.222, P = .001), triglycerides (r = 0.275, P < .001), and ALDO (P = .018 for linear trend). The patients were divided into low renin (low IR and ALDO levels), nonmodulators (normal PRA, high IR, and low ALDO levels), and modulators (normal PRA, intermediate IR, and normal ALDO levels) groups to assess the relative contribution of each factor to PAI-1 levels. Modulators had significantly (P = .019) higher PAI-1 levels compared to the low renin and nonmodulators who had similar PAI-1 levels. Conclusions: Plasma renin activity, IR, and ALDO all correlate with PAI-1 levels in the hypertensive subjects. However, the data suggest that ALDO may be an important factor contributing to the variability of PAI-1 levels in individual hypertensive subjects.

KW - Fibrinolysis

KW - Hypertension

KW - Renin-angiotensin system

UR - http://www.scopus.com/inward/record.url?scp=0035997355&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035997355&partnerID=8YFLogxK

U2 - 10.1016/S0895-7061(02)02952-7

DO - 10.1016/S0895-7061(02)02952-7

M3 - Article

C2 - 12160190

AN - SCOPUS:0035997355

VL - 15

SP - 683

EP - 690

JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

IS - 8

ER -