Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction

Senthil Selvaraj, R. M. Veerappan, M. Ramakrishna Rao, K. V. Pugalendi

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Background: Lipid peroxidation and derived oxidized products are being intensively investigated because of their potential to cause injury and because of their pathogenic role in several diseases. The view that an excess of lipid peroxidation products is present and is relevant in the pathogenesis of cardiogenic shock-induced damage has still not received definitive support. Methods: To evaluate the extent of lipid peroxidation, the status of enzymatic and nonenzymatic antioxidants in patients with cardiogenic shock that complicate acute myocardial infarction (AMI) and to compare with normal subjects. Results: Compared with normal subjects, cardiogenic shock patients had higher malondialdehyde, conjugated dienes and reduced activities of erythrocyte antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lower concentrations of reduced glutathione (GSH) in erythrocyte and in plasma GSH, vitamin C, vitamin E and in β-carotene. Conclusions: Cardiogenic shock is associated with greater than normal lipid peroxidation and with an imbalance in antioxidants' status. These results indicate that low activities of SOD, CAT, GPx and low concentrations of GSH, vitamin C, vitamin E and β-carotene in the circulation of patients with cardiogenic shock complicating AMI may be due to increased utilization to scavenge lipid peroxides. Decrease in plasma concentrations of GSH, vitamin E and β-carotene seems to be responsible for the elevation of lipid peroxidation in cardiogenic shock complicating AMI compared with MI.

Original languageEnglish
Pages (from-to)131-137
Number of pages7
JournalClinica Chimica Acta
Volume348
Issue number1-2
DOIs
Publication statusPublished - 1 Oct 2004
Externally publishedYes

Fingerprint

Oxidative stress
Cardiogenic Shock
Oxidative Stress
Antioxidants
Lipid Peroxidation
Myocardial Infarction
Lipids
Carotenoids
Vitamin E
Glutathione Peroxidase
Catalase
Ascorbic Acid
Superoxide Dismutase
Plasmas
Erythrocytes
Lipid Peroxides
Malondialdehyde
Glutathione
Enzymes
Wounds and Injuries

Keywords

  • Acute myocardial infarction
  • Antioxidants
  • Blood pressure
  • Cardiogenic shock
  • Hypotension
  • Lipid peroxidation

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction. / Selvaraj, Senthil; Veerappan, R. M.; Ramakrishna Rao, M.; Pugalendi, K. V.

In: Clinica Chimica Acta, Vol. 348, No. 1-2, 01.10.2004, p. 131-137.

Research output: Contribution to journalArticle

Selvaraj, Senthil ; Veerappan, R. M. ; Ramakrishna Rao, M. ; Pugalendi, K. V. / Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction. In: Clinica Chimica Acta. 2004 ; Vol. 348, No. 1-2. pp. 131-137.
@article{deafee730591466b91c580fcdf275f4a,
title = "Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction",
abstract = "Background: Lipid peroxidation and derived oxidized products are being intensively investigated because of their potential to cause injury and because of their pathogenic role in several diseases. The view that an excess of lipid peroxidation products is present and is relevant in the pathogenesis of cardiogenic shock-induced damage has still not received definitive support. Methods: To evaluate the extent of lipid peroxidation, the status of enzymatic and nonenzymatic antioxidants in patients with cardiogenic shock that complicate acute myocardial infarction (AMI) and to compare with normal subjects. Results: Compared with normal subjects, cardiogenic shock patients had higher malondialdehyde, conjugated dienes and reduced activities of erythrocyte antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lower concentrations of reduced glutathione (GSH) in erythrocyte and in plasma GSH, vitamin C, vitamin E and in β-carotene. Conclusions: Cardiogenic shock is associated with greater than normal lipid peroxidation and with an imbalance in antioxidants' status. These results indicate that low activities of SOD, CAT, GPx and low concentrations of GSH, vitamin C, vitamin E and β-carotene in the circulation of patients with cardiogenic shock complicating AMI may be due to increased utilization to scavenge lipid peroxides. Decrease in plasma concentrations of GSH, vitamin E and β-carotene seems to be responsible for the elevation of lipid peroxidation in cardiogenic shock complicating AMI compared with MI.",
keywords = "Acute myocardial infarction, Antioxidants, Blood pressure, Cardiogenic shock, Hypotension, Lipid peroxidation",
author = "Senthil Selvaraj and Veerappan, {R. M.} and {Ramakrishna Rao}, M. and Pugalendi, {K. V.}",
year = "2004",
month = "10",
day = "1",
doi = "10.1016/j.cccn.2004.05.004",
language = "English",
volume = "348",
pages = "131--137",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Oxidative stress and antioxidants in patients with cardiogenic shock complicating acute myocardial infarction

AU - Selvaraj, Senthil

AU - Veerappan, R. M.

AU - Ramakrishna Rao, M.

AU - Pugalendi, K. V.

PY - 2004/10/1

Y1 - 2004/10/1

N2 - Background: Lipid peroxidation and derived oxidized products are being intensively investigated because of their potential to cause injury and because of their pathogenic role in several diseases. The view that an excess of lipid peroxidation products is present and is relevant in the pathogenesis of cardiogenic shock-induced damage has still not received definitive support. Methods: To evaluate the extent of lipid peroxidation, the status of enzymatic and nonenzymatic antioxidants in patients with cardiogenic shock that complicate acute myocardial infarction (AMI) and to compare with normal subjects. Results: Compared with normal subjects, cardiogenic shock patients had higher malondialdehyde, conjugated dienes and reduced activities of erythrocyte antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lower concentrations of reduced glutathione (GSH) in erythrocyte and in plasma GSH, vitamin C, vitamin E and in β-carotene. Conclusions: Cardiogenic shock is associated with greater than normal lipid peroxidation and with an imbalance in antioxidants' status. These results indicate that low activities of SOD, CAT, GPx and low concentrations of GSH, vitamin C, vitamin E and β-carotene in the circulation of patients with cardiogenic shock complicating AMI may be due to increased utilization to scavenge lipid peroxides. Decrease in plasma concentrations of GSH, vitamin E and β-carotene seems to be responsible for the elevation of lipid peroxidation in cardiogenic shock complicating AMI compared with MI.

AB - Background: Lipid peroxidation and derived oxidized products are being intensively investigated because of their potential to cause injury and because of their pathogenic role in several diseases. The view that an excess of lipid peroxidation products is present and is relevant in the pathogenesis of cardiogenic shock-induced damage has still not received definitive support. Methods: To evaluate the extent of lipid peroxidation, the status of enzymatic and nonenzymatic antioxidants in patients with cardiogenic shock that complicate acute myocardial infarction (AMI) and to compare with normal subjects. Results: Compared with normal subjects, cardiogenic shock patients had higher malondialdehyde, conjugated dienes and reduced activities of erythrocyte antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and lower concentrations of reduced glutathione (GSH) in erythrocyte and in plasma GSH, vitamin C, vitamin E and in β-carotene. Conclusions: Cardiogenic shock is associated with greater than normal lipid peroxidation and with an imbalance in antioxidants' status. These results indicate that low activities of SOD, CAT, GPx and low concentrations of GSH, vitamin C, vitamin E and β-carotene in the circulation of patients with cardiogenic shock complicating AMI may be due to increased utilization to scavenge lipid peroxides. Decrease in plasma concentrations of GSH, vitamin E and β-carotene seems to be responsible for the elevation of lipid peroxidation in cardiogenic shock complicating AMI compared with MI.

KW - Acute myocardial infarction

KW - Antioxidants

KW - Blood pressure

KW - Cardiogenic shock

KW - Hypotension

KW - Lipid peroxidation

UR - http://www.scopus.com/inward/record.url?scp=4444226990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4444226990&partnerID=8YFLogxK

U2 - 10.1016/j.cccn.2004.05.004

DO - 10.1016/j.cccn.2004.05.004

M3 - Article

VL - 348

SP - 131

EP - 137

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

IS - 1-2

ER -