Output-feedback model predictive control of biological phenomena modeled by S-systems

N. Meskin, H. Nounou, M. Nounou, A. Datta, E. R. Dougherty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Recent years have witnessed extensive research activity in modeling biological phenomena as well as in developing intervention strategies for them. S-systems, which offer a good compromise between accuracy and mathematical flexibility, are a promising framework for modeling the dynamical behavior of biological phenomena. One of the main challenges for the development of intervention strategies for biological phenomena is that usually not all the variables (for instance, metabolite concentrations) are available for measurement. This can be due to the difficulty of or the cost associated with obtaining these measurements. Moreover, the available measurements may be noisy with a low sampling rate. In this paper, an intervention strategy is proposed for the S-system model in the presence of partial noisy measurements. In the proposed approach, first a stochastic nonlinear estimation algorithm, namely the unscented Kalman filter, is utilized for estimating the unmeasured variables of the S-system. Then, based on the estimated variables, a model predictive control algorithm is developed to guide the target variables to their desired values. The proposed intervention strategy is applied to the glycolytic-glycogenolytic pathway and the simulation result presented demonstrates the effectiveness of the proposed scheme.

Original languageEnglish
Title of host publication2012 American Control Conference, ACC 2012
Number of pages6
Publication statusPublished - 26 Nov 2012
Event2012 American Control Conference, ACC 2012 - Montreal, QC, Canada
Duration: 27 Jun 201229 Jun 2012

Publication series

NameProceedings of the American Control Conference
ISSN (Print)0743-1619


Other2012 American Control Conference, ACC 2012
CityMontreal, QC


ASJC Scopus subject areas

  • Electrical and Electronic Engineering

Cite this

Meskin, N., Nounou, H., Nounou, M., Datta, A., & Dougherty, E. R. (2012). Output-feedback model predictive control of biological phenomena modeled by S-systems. In 2012 American Control Conference, ACC 2012 (pp. 1979-1984). [6314815] (Proceedings of the American Control Conference).