Organ Weaving: Woven Threads and Sheets As a Step Towards a New Strategy for Artificial Organ Development

Albert R. Liberski, Joseph T. Delaney, Hendrik Schäfer, Jolke Perelaer, Ulrich S. Schubert

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The concept of "organ weaving" is presented, a fabrication technique that can be an attractive option for the development of artificial tissues and organs. "Living threads" are created by immersing threads that are soaked in a CaCl2 solution into a sodium-alginate-loaded cell suspension bath, encapsulating the cells and creating a bio-friendly, easily manageable starting material for building up larger scaffold structures. Such living threads have the advantage of being a particularly mild culturing medium for mammalian cells, protecting the cells during subsequent processing steps from dehydration and other rapid changes in the chemistry of the surrounding environment. Connecting different types of threads into 3D objects gives unique opportunities to address tissue engineering challenges. The new concept of "organ weaving"is presented. It forms an attractive option for the development of artificial tissues and organs. By immersing threads that are soaked in a calcium chloride solution into a sodium-alginate-loaded cell suspension bath, which encapsulates the cells, "living threads" are created that are bio-friendly and easily manageable as starting materials for building up larger scaffold structures.

Original languageEnglish
Pages (from-to)1491-1498
Number of pages8
JournalMacromolecular Bioscience
Volume11
Issue number11
DOIs
Publication statusPublished - 10 Nov 2011
Externally publishedYes

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Keywords

  • Fibers
  • Hydrogels
  • Matrix
  • Structure
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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