Abstract
Purpose (i) To optimize an MR-compatible organ perfusion setup for the nondestructive investigation of isolated rat hearts by placing the radiofrequency (RF) coil inside the perfusion chamber; (ii) to characterize the benefit of this system for diffusion tensor imaging and proton (<sup>1</sup>H-) MR spectroscopy. Methods Coil quality assessment was conducted both on the bench, and in the magnet. The benefit of the new RF-coil was quantified by measuring signal-to-noise ratio (SNR), accuracy, and precision of diffusion tensor imaging/error in metabolite amplitude estimation, and compared to an RF-coil placed externally to the perfusion chamber. Results The new design provided a 59% gain in signal-to-noise ratio on a fixed rat heart compared to using an external resonator, which found reflection in an improvement of living heart data quality, compared to previous external resonator studies. This resulted in 14-29% improvement in accuracy and precision of diffusion tensor imaging. The Cramer-Rao lower bounds for metabolite amplitude estimations were up to 5-fold smaller. Conclusion Optimization of MR-compatible perfusion equipment advances the study of rat hearts with improved signal-to-noise ratio performance, and thus improved accuracy/precision. Magn Reson Med 73:2398-2405, 2015.
| Original language | English |
|---|---|
| Pages (from-to) | 2398-2405 |
| Number of pages | 8 |
| Journal | Magnetic Resonance in Medicine |
| Volume | 73 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Jun 2015 |
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Keywords
- cardiac magnetic resonance imaging
- diffusion tensor imaging
- Langendorff perfusion
- proton spectroscopy
- radiofrequency coil
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Optimized radiofrequency coil setup for MR examination of living isolated rat hearts in a horizontal 9.4T magnet. / Lohezic, Maelene; Bollensdorff, Christian; Korn, Matthias; Lanz, Titus; Grau, Vicente; Kohl, Peter; Schneider, Jürgen E.
In: Magnetic Resonance in Medicine, Vol. 73, No. 6, 01.06.2015, p. 2398-2405.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Optimized radiofrequency coil setup for MR examination of living isolated rat hearts in a horizontal 9.4T magnet
AU - Lohezic, Maelene
AU - Bollensdorff, Christian
AU - Korn, Matthias
AU - Lanz, Titus
AU - Grau, Vicente
AU - Kohl, Peter
AU - Schneider, Jürgen E.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - Purpose (i) To optimize an MR-compatible organ perfusion setup for the nondestructive investigation of isolated rat hearts by placing the radiofrequency (RF) coil inside the perfusion chamber; (ii) to characterize the benefit of this system for diffusion tensor imaging and proton (1H-) MR spectroscopy. Methods Coil quality assessment was conducted both on the bench, and in the magnet. The benefit of the new RF-coil was quantified by measuring signal-to-noise ratio (SNR), accuracy, and precision of diffusion tensor imaging/error in metabolite amplitude estimation, and compared to an RF-coil placed externally to the perfusion chamber. Results The new design provided a 59% gain in signal-to-noise ratio on a fixed rat heart compared to using an external resonator, which found reflection in an improvement of living heart data quality, compared to previous external resonator studies. This resulted in 14-29% improvement in accuracy and precision of diffusion tensor imaging. The Cramer-Rao lower bounds for metabolite amplitude estimations were up to 5-fold smaller. Conclusion Optimization of MR-compatible perfusion equipment advances the study of rat hearts with improved signal-to-noise ratio performance, and thus improved accuracy/precision. Magn Reson Med 73:2398-2405, 2015.
AB - Purpose (i) To optimize an MR-compatible organ perfusion setup for the nondestructive investigation of isolated rat hearts by placing the radiofrequency (RF) coil inside the perfusion chamber; (ii) to characterize the benefit of this system for diffusion tensor imaging and proton (1H-) MR spectroscopy. Methods Coil quality assessment was conducted both on the bench, and in the magnet. The benefit of the new RF-coil was quantified by measuring signal-to-noise ratio (SNR), accuracy, and precision of diffusion tensor imaging/error in metabolite amplitude estimation, and compared to an RF-coil placed externally to the perfusion chamber. Results The new design provided a 59% gain in signal-to-noise ratio on a fixed rat heart compared to using an external resonator, which found reflection in an improvement of living heart data quality, compared to previous external resonator studies. This resulted in 14-29% improvement in accuracy and precision of diffusion tensor imaging. The Cramer-Rao lower bounds for metabolite amplitude estimations were up to 5-fold smaller. Conclusion Optimization of MR-compatible perfusion equipment advances the study of rat hearts with improved signal-to-noise ratio performance, and thus improved accuracy/precision. Magn Reson Med 73:2398-2405, 2015.
KW - cardiac magnetic resonance imaging
KW - diffusion tensor imaging
KW - Langendorff perfusion
KW - proton spectroscopy
KW - radiofrequency coil
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UR - http://www.scopus.com/inward/citedby.url?scp=84929654317&partnerID=8YFLogxK
U2 - 10.1002/mrm.25369
DO - 10.1002/mrm.25369
M3 - Article
C2 - 25045897
AN - SCOPUS:84929654317
VL - 73
SP - 2398
EP - 2405
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
SN - 0740-3194
IS - 6
ER -