Optimized radiofrequency coil setup for MR examination of living isolated rat hearts in a horizontal 9.4T magnet

Maelene Lohezic, Christian Bollensdorff, Matthias Korn, Titus Lanz, Vicente Grau, Peter Kohl, Jürgen E. Schneider

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Purpose (i) To optimize an MR-compatible organ perfusion setup for the nondestructive investigation of isolated rat hearts by placing the radiofrequency (RF) coil inside the perfusion chamber; (ii) to characterize the benefit of this system for diffusion tensor imaging and proton (<sup>1</sup>H-) MR spectroscopy. Methods Coil quality assessment was conducted both on the bench, and in the magnet. The benefit of the new RF-coil was quantified by measuring signal-to-noise ratio (SNR), accuracy, and precision of diffusion tensor imaging/error in metabolite amplitude estimation, and compared to an RF-coil placed externally to the perfusion chamber. Results The new design provided a 59% gain in signal-to-noise ratio on a fixed rat heart compared to using an external resonator, which found reflection in an improvement of living heart data quality, compared to previous external resonator studies. This resulted in 14-29% improvement in accuracy and precision of diffusion tensor imaging. The Cramer-Rao lower bounds for metabolite amplitude estimations were up to 5-fold smaller. Conclusion Optimization of MR-compatible perfusion equipment advances the study of rat hearts with improved signal-to-noise ratio performance, and thus improved accuracy/precision. Magn Reson Med 73:2398-2405, 2015.

    Original languageEnglish
    Pages (from-to)2398-2405
    Number of pages8
    JournalMagnetic Resonance in Medicine
    Volume73
    Issue number6
    DOIs
    Publication statusPublished - 1 Jun 2015

    Fingerprint

    Magnets
    Diffusion Tensor Imaging
    Signal-To-Noise Ratio
    Perfusion
    Protons
    Magnetic Resonance Spectroscopy
    Equipment and Supplies

    Keywords

    • cardiac magnetic resonance imaging
    • diffusion tensor imaging
    • Langendorff perfusion
    • proton spectroscopy
    • radiofrequency coil

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

    Cite this

    Lohezic, M., Bollensdorff, C., Korn, M., Lanz, T., Grau, V., Kohl, P., & Schneider, J. E. (2015). Optimized radiofrequency coil setup for MR examination of living isolated rat hearts in a horizontal 9.4T magnet. Magnetic Resonance in Medicine, 73(6), 2398-2405. https://doi.org/10.1002/mrm.25369

    Optimized radiofrequency coil setup for MR examination of living isolated rat hearts in a horizontal 9.4T magnet. / Lohezic, Maelene; Bollensdorff, Christian; Korn, Matthias; Lanz, Titus; Grau, Vicente; Kohl, Peter; Schneider, Jürgen E.

    In: Magnetic Resonance in Medicine, Vol. 73, No. 6, 01.06.2015, p. 2398-2405.

    Research output: Contribution to journalArticle

    Lohezic, M, Bollensdorff, C, Korn, M, Lanz, T, Grau, V, Kohl, P & Schneider, JE 2015, 'Optimized radiofrequency coil setup for MR examination of living isolated rat hearts in a horizontal 9.4T magnet', Magnetic Resonance in Medicine, vol. 73, no. 6, pp. 2398-2405. https://doi.org/10.1002/mrm.25369
    Lohezic, Maelene ; Bollensdorff, Christian ; Korn, Matthias ; Lanz, Titus ; Grau, Vicente ; Kohl, Peter ; Schneider, Jürgen E. / Optimized radiofrequency coil setup for MR examination of living isolated rat hearts in a horizontal 9.4T magnet. In: Magnetic Resonance in Medicine. 2015 ; Vol. 73, No. 6. pp. 2398-2405.
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