Optical coherence tomography predicts 4-year incident diabetic neuropathy

Sangeetha Srinivasan, Cirous Dehghani, Nicola Pritchard, Katie Edwards, Anthony W. Russell, Rayaz Malik, Nathan Efron

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: To examine the capability of optical coherence tomography-derived retinal thickness measures in detecting 4-year incident diabetic peripheral neuropathy (DPN). Methods: 145 eyes of 145 participants with diabetes but no DPN at baseline were examined for incident DPN. HbA1c levels, nephropathy, neuropathy (DPN), cardiovascular measures, and various retinal thickness measures were examined at baseline and after 4 years. Incidence of DPN was defined as newly developed DPN at follow-up. Baseline factors were assessed by univariate and a step-wise multiple logistic regression, and the predictors were examined for diagnostic capabilities. Results: Of the 145 participants without DPN at baseline, 51 had developed DPN when examined after 4 years (35% incidence). Of the ophthalmic variables, the mean (S.D.) of the overall thickness in the parafovea at baseline was 315 (18) μm in the no DPN group and 306 (18) μm in the ‘incidence’ group, and the differences were significant, p = 0.005. The superior hemisphere parafovea (mean (S.D.): 318 (17) μm vs 310 (20) μm, p = 0.02) and inferior hemisphere parafovea (313 (19) μm vs 302 (18) μm, p = 0.002) were different in the incident DPN group compared with the no DPN group. When adjusted for age, retinal thickness in the parafovea (AUC = 0.65, p = 0.003, 86% sensitivity and 44% specificity at 321 μm criterion), and body mass index or BMI (AUC = 0.65, p = 0.003, 49% sensitivity and 83% specificity at 29.3 kg m−2 criterion) at baseline were significant predictors for 4-year incident DPN. Conclusions: A lower retinal thickness at the parafovea and a higher BMI can predict 4-year incident neuropathy in patients with diabetes, with acceptable diagnostic accuracies. This OCT-derived measure may serve as a potential ophthalmic marker in the screening of patients at risk of developing DPN.

Original languageEnglish
Pages (from-to)451-459
Number of pages9
JournalOphthalmic and Physiological Optics
Volume37
Issue number4
DOIs
Publication statusPublished - 1 Jul 2017

Fingerprint

Diabetic Neuropathies
Optical Coherence Tomography
Peripheral Nervous System Diseases
Area Under Curve
Incidence
Sensitivity and Specificity
Diabetic Nephropathies
Body Mass Index
Logistic Models

Keywords

  • diabetes
  • neuropathy
  • optical coherence tomography
  • retinal thickness

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry
  • Sensory Systems

Cite this

Srinivasan, S., Dehghani, C., Pritchard, N., Edwards, K., Russell, A. W., Malik, R., & Efron, N. (2017). Optical coherence tomography predicts 4-year incident diabetic neuropathy. Ophthalmic and Physiological Optics, 37(4), 451-459. https://doi.org/10.1111/opo.12391

Optical coherence tomography predicts 4-year incident diabetic neuropathy. / Srinivasan, Sangeetha; Dehghani, Cirous; Pritchard, Nicola; Edwards, Katie; Russell, Anthony W.; Malik, Rayaz; Efron, Nathan.

In: Ophthalmic and Physiological Optics, Vol. 37, No. 4, 01.07.2017, p. 451-459.

Research output: Contribution to journalArticle

Srinivasan, S, Dehghani, C, Pritchard, N, Edwards, K, Russell, AW, Malik, R & Efron, N 2017, 'Optical coherence tomography predicts 4-year incident diabetic neuropathy', Ophthalmic and Physiological Optics, vol. 37, no. 4, pp. 451-459. https://doi.org/10.1111/opo.12391
Srinivasan, Sangeetha ; Dehghani, Cirous ; Pritchard, Nicola ; Edwards, Katie ; Russell, Anthony W. ; Malik, Rayaz ; Efron, Nathan. / Optical coherence tomography predicts 4-year incident diabetic neuropathy. In: Ophthalmic and Physiological Optics. 2017 ; Vol. 37, No. 4. pp. 451-459.
@article{cc066193556847e2a386e6904857727f,
title = "Optical coherence tomography predicts 4-year incident diabetic neuropathy",
abstract = "Purpose: To examine the capability of optical coherence tomography-derived retinal thickness measures in detecting 4-year incident diabetic peripheral neuropathy (DPN). Methods: 145 eyes of 145 participants with diabetes but no DPN at baseline were examined for incident DPN. HbA1c levels, nephropathy, neuropathy (DPN), cardiovascular measures, and various retinal thickness measures were examined at baseline and after 4 years. Incidence of DPN was defined as newly developed DPN at follow-up. Baseline factors were assessed by univariate and a step-wise multiple logistic regression, and the predictors were examined for diagnostic capabilities. Results: Of the 145 participants without DPN at baseline, 51 had developed DPN when examined after 4 years (35{\%} incidence). Of the ophthalmic variables, the mean (S.D.) of the overall thickness in the parafovea at baseline was 315 (18) μm in the no DPN group and 306 (18) μm in the ‘incidence’ group, and the differences were significant, p = 0.005. The superior hemisphere parafovea (mean (S.D.): 318 (17) μm vs 310 (20) μm, p = 0.02) and inferior hemisphere parafovea (313 (19) μm vs 302 (18) μm, p = 0.002) were different in the incident DPN group compared with the no DPN group. When adjusted for age, retinal thickness in the parafovea (AUC = 0.65, p = 0.003, 86{\%} sensitivity and 44{\%} specificity at 321 μm criterion), and body mass index or BMI (AUC = 0.65, p = 0.003, 49{\%} sensitivity and 83{\%} specificity at 29.3 kg m−2 criterion) at baseline were significant predictors for 4-year incident DPN. Conclusions: A lower retinal thickness at the parafovea and a higher BMI can predict 4-year incident neuropathy in patients with diabetes, with acceptable diagnostic accuracies. This OCT-derived measure may serve as a potential ophthalmic marker in the screening of patients at risk of developing DPN.",
keywords = "diabetes, neuropathy, optical coherence tomography, retinal thickness",
author = "Sangeetha Srinivasan and Cirous Dehghani and Nicola Pritchard and Katie Edwards and Russell, {Anthony W.} and Rayaz Malik and Nathan Efron",
year = "2017",
month = "7",
day = "1",
doi = "10.1111/opo.12391",
language = "English",
volume = "37",
pages = "451--459",
journal = "Ophthalmic and Physiological Optics",
issn = "0275-5408",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Optical coherence tomography predicts 4-year incident diabetic neuropathy

AU - Srinivasan, Sangeetha

AU - Dehghani, Cirous

AU - Pritchard, Nicola

AU - Edwards, Katie

AU - Russell, Anthony W.

AU - Malik, Rayaz

AU - Efron, Nathan

PY - 2017/7/1

Y1 - 2017/7/1

N2 - Purpose: To examine the capability of optical coherence tomography-derived retinal thickness measures in detecting 4-year incident diabetic peripheral neuropathy (DPN). Methods: 145 eyes of 145 participants with diabetes but no DPN at baseline were examined for incident DPN. HbA1c levels, nephropathy, neuropathy (DPN), cardiovascular measures, and various retinal thickness measures were examined at baseline and after 4 years. Incidence of DPN was defined as newly developed DPN at follow-up. Baseline factors were assessed by univariate and a step-wise multiple logistic regression, and the predictors were examined for diagnostic capabilities. Results: Of the 145 participants without DPN at baseline, 51 had developed DPN when examined after 4 years (35% incidence). Of the ophthalmic variables, the mean (S.D.) of the overall thickness in the parafovea at baseline was 315 (18) μm in the no DPN group and 306 (18) μm in the ‘incidence’ group, and the differences were significant, p = 0.005. The superior hemisphere parafovea (mean (S.D.): 318 (17) μm vs 310 (20) μm, p = 0.02) and inferior hemisphere parafovea (313 (19) μm vs 302 (18) μm, p = 0.002) were different in the incident DPN group compared with the no DPN group. When adjusted for age, retinal thickness in the parafovea (AUC = 0.65, p = 0.003, 86% sensitivity and 44% specificity at 321 μm criterion), and body mass index or BMI (AUC = 0.65, p = 0.003, 49% sensitivity and 83% specificity at 29.3 kg m−2 criterion) at baseline were significant predictors for 4-year incident DPN. Conclusions: A lower retinal thickness at the parafovea and a higher BMI can predict 4-year incident neuropathy in patients with diabetes, with acceptable diagnostic accuracies. This OCT-derived measure may serve as a potential ophthalmic marker in the screening of patients at risk of developing DPN.

AB - Purpose: To examine the capability of optical coherence tomography-derived retinal thickness measures in detecting 4-year incident diabetic peripheral neuropathy (DPN). Methods: 145 eyes of 145 participants with diabetes but no DPN at baseline were examined for incident DPN. HbA1c levels, nephropathy, neuropathy (DPN), cardiovascular measures, and various retinal thickness measures were examined at baseline and after 4 years. Incidence of DPN was defined as newly developed DPN at follow-up. Baseline factors were assessed by univariate and a step-wise multiple logistic regression, and the predictors were examined for diagnostic capabilities. Results: Of the 145 participants without DPN at baseline, 51 had developed DPN when examined after 4 years (35% incidence). Of the ophthalmic variables, the mean (S.D.) of the overall thickness in the parafovea at baseline was 315 (18) μm in the no DPN group and 306 (18) μm in the ‘incidence’ group, and the differences were significant, p = 0.005. The superior hemisphere parafovea (mean (S.D.): 318 (17) μm vs 310 (20) μm, p = 0.02) and inferior hemisphere parafovea (313 (19) μm vs 302 (18) μm, p = 0.002) were different in the incident DPN group compared with the no DPN group. When adjusted for age, retinal thickness in the parafovea (AUC = 0.65, p = 0.003, 86% sensitivity and 44% specificity at 321 μm criterion), and body mass index or BMI (AUC = 0.65, p = 0.003, 49% sensitivity and 83% specificity at 29.3 kg m−2 criterion) at baseline were significant predictors for 4-year incident DPN. Conclusions: A lower retinal thickness at the parafovea and a higher BMI can predict 4-year incident neuropathy in patients with diabetes, with acceptable diagnostic accuracies. This OCT-derived measure may serve as a potential ophthalmic marker in the screening of patients at risk of developing DPN.

KW - diabetes

KW - neuropathy

KW - optical coherence tomography

KW - retinal thickness

UR - http://www.scopus.com/inward/record.url?scp=85021385324&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85021385324&partnerID=8YFLogxK

U2 - 10.1111/opo.12391

DO - 10.1111/opo.12391

M3 - Article

VL - 37

SP - 451

EP - 459

JO - Ophthalmic and Physiological Optics

JF - Ophthalmic and Physiological Optics

SN - 0275-5408

IS - 4

ER -