One-step synthesis of an antimicrobial framework based on covalently cross-linked chitosan/lignosulfonate (CS@LS) nanospheres

Ravi P. Pandey, Kashif Rasool, P. Abdul Rasheed, Tricia Gomez, Mujaheed Pasha, Said A. Mansour, One Sun Lee, Khaled A. Mahmoud

Research output: Contribution to journalArticle


Herein, renewable and uniform nanospheres based on chitosan (CS) and lignosulfonate (LS): (CS@LS) were designed for the first time through a simple one-step covalent cross-linking protocol. Experimental and theoretical pieces of evidence have proven the self-assembled structure of the nanospheres as a binary network between CS and LS. The optimum composite structure was formed at CS@LS 1 : 1 ratio, with a characteristic domain size in the range of 150-200 nm. The amphiphilic nanospheres demonstrated high thermal, mechanical, and bactericidal properties. The CS@LS-1 : 1 nanosphere demonstrated high growth inhibition towards aerobic Gram (-) E. coli and Gram (+) B. subtilis and anaerobic sulfate-reducing bacteria (SRB) making them ideal biocides for water disinfection. This work provides an important synthesis guideline for the development of green biomimetic nanomaterials for a plethora of applications, where a uniform size and shape are crucial success criteria.

Original languageEnglish
Pages (from-to)678-687
Number of pages10
JournalGreen Chemistry
Issue number3
Publication statusPublished - 7 Feb 2020


ASJC Scopus subject areas

  • Environmental Chemistry
  • Pollution

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