One-pot total chemical synthesis of human α-synuclein

Bruno Fauvet, Sara M. Butterfield, Jonas Fuks, Ashraf Brik, Hilal A. Lashuel

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25 Citations (Scopus)

Abstract

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson’s disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

Original languageEnglish
Pages (from-to)9254-9256
Number of pages3
JournalChemical Communications
Volume49
Issue number81
DOIs
Publication statusPublished - 17 Sep 2013

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ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Fauvet, B., Butterfield, S. M., Fuks, J., Brik, A., & Lashuel, H. A. (2013). One-pot total chemical synthesis of human α-synuclein. Chemical Communications, 49(81), 9254-9256. https://doi.org/10.1039/c3cc45353g