One-pot total chemical synthesis of human α-synuclein

Bruno Fauvet, Sara M. Butterfield, Jonas Fuks, Ashraf Brik, Hilal A. Lashuel

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Post-translational modifications (PTMs) regulate key aspects of the physiological and pathogenic properties of Parkinson's disease-associated presynaptic protein α-synuclein. We herein describe a one-pot total chemical synthesis that should enable site-specific introduction of single or multiple PTMs or small molecule probes essentially at any site within the protein.

Original languageEnglish
Pages (from-to)9254-9256
Number of pages3
JournalChemical Communications
Volume49
Issue number81
DOIs
Publication statusPublished - 18 Oct 2013
Externally publishedYes

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Synucleins
Post Translational Protein Processing
Proteins
Molecules

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Fauvet, B., Butterfield, S. M., Fuks, J., Brik, A., & Lashuel, H. A. (2013). One-pot total chemical synthesis of human α-synuclein. Chemical Communications, 49(81), 9254-9256. https://doi.org/10.1039/c3cc45353g

One-pot total chemical synthesis of human α-synuclein. / Fauvet, Bruno; Butterfield, Sara M.; Fuks, Jonas; Brik, Ashraf; Lashuel, Hilal A.

In: Chemical Communications, Vol. 49, No. 81, 18.10.2013, p. 9254-9256.

Research output: Contribution to journalArticle

Fauvet, B, Butterfield, SM, Fuks, J, Brik, A & Lashuel, HA 2013, 'One-pot total chemical synthesis of human α-synuclein', Chemical Communications, vol. 49, no. 81, pp. 9254-9256. https://doi.org/10.1039/c3cc45353g
Fauvet B, Butterfield SM, Fuks J, Brik A, Lashuel HA. One-pot total chemical synthesis of human α-synuclein. Chemical Communications. 2013 Oct 18;49(81):9254-9256. https://doi.org/10.1039/c3cc45353g
Fauvet, Bruno ; Butterfield, Sara M. ; Fuks, Jonas ; Brik, Ashraf ; Lashuel, Hilal A. / One-pot total chemical synthesis of human α-synuclein. In: Chemical Communications. 2013 ; Vol. 49, No. 81. pp. 9254-9256.
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