Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm

Masayuki Kimura, Lynn F. Cherkas, Bernet S. Kato, Serkalem Demissie, Jacob B. Hjelmborg, Michael Brimacombe, Adrienne Cupples, Janice L. Hunkin, Jefferey P. Gardner, Xiaobin Lu, Xiaojian Cao, Malinee Sastrasinh, Michael A. Province, Steven Hunt, Kaare Christensen, Daniel Levy, Tim D. Spector, Abraham Aviv

Research output: Contribution to journalArticle

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Abstract

Leukocyte telomere length (LTL) is a complex genetic trait. It shortens with age and is associated with a host of aging-related disorders. Recent studies have observed that offspring of older fathers have longer LTLs. We explored the relation between paternal age and offspring's LTLs in 4 different cohorts. Moreover, we examined the potential cause of the paternal age on offspring's LTL by delineating telomere parameters in sperm donors. We measured LTL by Southern blots in Caucasian men and women (n=3365), aged 18-94 years, from the Offspring of the Framingham Heart Study (Framingham Offspring), the NHLBI Family Heart Study (NHLBI-Heart), the Longitudinal Study of Aging Danish Twins (Danish Twins), and the UK Adult Twin Registry (UK Twins). Using Southern blots, Q-FISH, and flow-FISH, we also measured telomere parameters in sperm from 46 young (<30 years) and older (>50 years) donors. Paternal age had an independent effect, expressed by a longer LTL in males of the Framingham Offspring and Danish Twins, males and females of the NHLBI-Heart, and females of UK Twins. For every additional year of paternal age, LTL in offspring increased at a magnitude ranging from half to more than twice of the annual attrition in LTL with age. Moreover, sperm telomere length analyses were compatible with the emergence in older men of a subset of sperm with elongated telomeres. Paternal age exerts a considerable effect on the offspring's LTL, a phenomenon which might relate to telomere elongation in sperm from older men. The implications of this effect deserve detailed study.

Original languageEnglish
JournalPLoS Genetics
Volume4
Issue number2
DOIs
Publication statusPublished - Feb 2008
Externally publishedYes

Fingerprint

Paternal Age
telomeres
Telomere
sperm
Spermatozoa
leukocytes
Leukocytes
spermatozoa
National Heart, Lung, and Blood Institute (U.S.)
heart
Southern Blotting
Southern blotting
Tissue Donors
genetic traits
fathers
longitudinal studies
Fathers

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

Cite this

Kimura, M., Cherkas, L. F., Kato, B. S., Demissie, S., Hjelmborg, J. B., Brimacombe, M., ... Aviv, A. (2008). Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genetics, 4(2). https://doi.org/10.1371/journal.pgen.0040037

Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. / Kimura, Masayuki; Cherkas, Lynn F.; Kato, Bernet S.; Demissie, Serkalem; Hjelmborg, Jacob B.; Brimacombe, Michael; Cupples, Adrienne; Hunkin, Janice L.; Gardner, Jefferey P.; Lu, Xiaobin; Cao, Xiaojian; Sastrasinh, Malinee; Province, Michael A.; Hunt, Steven; Christensen, Kaare; Levy, Daniel; Spector, Tim D.; Aviv, Abraham.

In: PLoS Genetics, Vol. 4, No. 2, 02.2008.

Research output: Contribution to journalArticle

Kimura, M, Cherkas, LF, Kato, BS, Demissie, S, Hjelmborg, JB, Brimacombe, M, Cupples, A, Hunkin, JL, Gardner, JP, Lu, X, Cao, X, Sastrasinh, M, Province, MA, Hunt, S, Christensen, K, Levy, D, Spector, TD & Aviv, A 2008, 'Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm', PLoS Genetics, vol. 4, no. 2. https://doi.org/10.1371/journal.pgen.0040037
Kimura M, Cherkas LF, Kato BS, Demissie S, Hjelmborg JB, Brimacombe M et al. Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. PLoS Genetics. 2008 Feb;4(2). https://doi.org/10.1371/journal.pgen.0040037
Kimura, Masayuki ; Cherkas, Lynn F. ; Kato, Bernet S. ; Demissie, Serkalem ; Hjelmborg, Jacob B. ; Brimacombe, Michael ; Cupples, Adrienne ; Hunkin, Janice L. ; Gardner, Jefferey P. ; Lu, Xiaobin ; Cao, Xiaojian ; Sastrasinh, Malinee ; Province, Michael A. ; Hunt, Steven ; Christensen, Kaare ; Levy, Daniel ; Spector, Tim D. ; Aviv, Abraham. / Offspring's leukocyte telomere length, paternal age, and telomere elongation in sperm. In: PLoS Genetics. 2008 ; Vol. 4, No. 2.
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