Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population

Sara Tomei, Ravinder Mamtani, Rashid Al Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A. Rouh, Idil I. Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh KhannaEna Wang, Dhanya Kizhakayil, Al Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M. Marincola, Javaid Sheikh, Lotfi Chouchane

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10 Citations (Scopus)

Abstract

Objectives: In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. Methods: Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m2); 131 overweight (25 kg/m2 ≤ BMI < 30 kg/m2) and 483 obese (BMI > 30 kg/m2). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan. Results: Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358). Conclusion: We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.

Original languageEnglish
Article number119
JournalJournal of translational medicine
Volume13
Issue number1
DOIs
Publication statusPublished - 12 Dec 2015

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Keywords

  • Body mass index
  • Genotyping
  • Obesity
  • Qatar
  • Single Nucleotide Polymorphism (SNP)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Tomei, S., Mamtani, R., Al Ali, R., Elkum, N., Abdulmalik, M., Ismail, A., Cheema, S., Rouh, H. A., Aigha, I. I., Hani, F., Al-Samraye, S., Taher Aseel, M., El Emadi, N., Al Mujalli, A., Abdelkerim, A., Youssif, S., Worschech, A., El Sebakhy, E., Temanni, R., ... Chouchane, L. (2015). Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population. Journal of translational medicine, 13(1), [119]. https://doi.org/10.1186/s12967-015-0459-3