Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population

Sara Tomei, Ravinder Mamtani, Rashid J. Al-Ali, Naser Elkum, Maryam Abdulmalik, Awatef Ismail, Sohaila Cheema, Hekmat A. Rouh, Idil I. Aigha, Fatima Hani, Sura Al-Samraye, Mona Taher Aseel, Nada El Emadi, Azza Al Mujalli, Ahmed Abdelkerim, Siddik Youssif, Andrea Worschech, Emad El Sebakhy, Ramzi Temanni, Vineesh Khanna & 8 others Ena Wang, Dhanya Kizhakayil, Al Anood Al-Thani, Mohammed Al-Thani, Albert Lowenfels, Francesco M. Marincola, Javaid Sheikh, Lotfi Chouchane

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Objectives: In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. Methods: Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m2); 131 overweight (25 kg/m2 ≤ BMI < 30 kg/m2) and 483 obese (BMI > 30 kg/m2). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan. Results: Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358). Conclusion: We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.

Original languageEnglish
Article number119
JournalJournal of Translational Medicine
Volume13
Issue number1
DOIs
Publication statusPublished - 13 Apr 2015

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Blood
Obesity
Alleles
DNA
Population
Body Mass Index
Genotype
Consanguinity

Keywords

  • Body mass index
  • Genotyping
  • Obesity
  • Qatar
  • Single Nucleotide Polymorphism (SNP)

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population. / Tomei, Sara; Mamtani, Ravinder; Al-Ali, Rashid J.; Elkum, Naser; Abdulmalik, Maryam; Ismail, Awatef; Cheema, Sohaila; Rouh, Hekmat A.; Aigha, Idil I.; Hani, Fatima; Al-Samraye, Sura; Taher Aseel, Mona; El Emadi, Nada; Al Mujalli, Azza; Abdelkerim, Ahmed; Youssif, Siddik; Worschech, Andrea; El Sebakhy, Emad; Temanni, Ramzi; Khanna, Vineesh; Wang, Ena; Kizhakayil, Dhanya; Al-Thani, Al Anood; Al-Thani, Mohammed; Lowenfels, Albert; Marincola, Francesco M.; Sheikh, Javaid; Chouchane, Lotfi.

In: Journal of Translational Medicine, Vol. 13, No. 1, 119, 13.04.2015.

Research output: Contribution to journalArticle

Tomei, S, Mamtani, R, Al-Ali, RJ, Elkum, N, Abdulmalik, M, Ismail, A, Cheema, S, Rouh, HA, Aigha, II, Hani, F, Al-Samraye, S, Taher Aseel, M, El Emadi, N, Al Mujalli, A, Abdelkerim, A, Youssif, S, Worschech, A, El Sebakhy, E, Temanni, R, Khanna, V, Wang, E, Kizhakayil, D, Al-Thani, AA, Al-Thani, M, Lowenfels, A, Marincola, FM, Sheikh, J & Chouchane, L 2015, 'Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population', Journal of Translational Medicine, vol. 13, no. 1, 119. https://doi.org/10.1186/s12967-015-0459-3
Tomei, Sara ; Mamtani, Ravinder ; Al-Ali, Rashid J. ; Elkum, Naser ; Abdulmalik, Maryam ; Ismail, Awatef ; Cheema, Sohaila ; Rouh, Hekmat A. ; Aigha, Idil I. ; Hani, Fatima ; Al-Samraye, Sura ; Taher Aseel, Mona ; El Emadi, Nada ; Al Mujalli, Azza ; Abdelkerim, Ahmed ; Youssif, Siddik ; Worschech, Andrea ; El Sebakhy, Emad ; Temanni, Ramzi ; Khanna, Vineesh ; Wang, Ena ; Kizhakayil, Dhanya ; Al-Thani, Al Anood ; Al-Thani, Mohammed ; Lowenfels, Albert ; Marincola, Francesco M. ; Sheikh, Javaid ; Chouchane, Lotfi. / Obesity susceptibility loci in Qataris, a highly consanguineous Arabian population. In: Journal of Translational Medicine. 2015 ; Vol. 13, No. 1.
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AU - Mamtani, Ravinder

AU - Al-Ali, Rashid J.

AU - Elkum, Naser

AU - Abdulmalik, Maryam

AU - Ismail, Awatef

AU - Cheema, Sohaila

AU - Rouh, Hekmat A.

AU - Aigha, Idil I.

AU - Hani, Fatima

AU - Al-Samraye, Sura

AU - Taher Aseel, Mona

AU - El Emadi, Nada

AU - Al Mujalli, Azza

AU - Abdelkerim, Ahmed

AU - Youssif, Siddik

AU - Worschech, Andrea

AU - El Sebakhy, Emad

AU - Temanni, Ramzi

AU - Khanna, Vineesh

AU - Wang, Ena

AU - Kizhakayil, Dhanya

AU - Al-Thani, Al Anood

AU - Al-Thani, Mohammed

AU - Lowenfels, Albert

AU - Marincola, Francesco M.

AU - Sheikh, Javaid

AU - Chouchane, Lotfi

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N2 - Objectives: In Qataris, a population characterized by a small size and a high rate of consanguinity, between two-thirds to three-quarters of adults are overweight or obese. We investigated the relevance of 23 obesity-related loci in the Qatari population. Methods: Eight-hundred-four individuals assessed to be third generation Qataris were included in the study and assigned to 3 groups according to their body mass index (BMI): 190 lean (BMI < 25 kg/m2); 131 overweight (25 kg/m2 ≤ BMI < 30 kg/m2) and 483 obese (BMI > 30 kg/m2). Genomic DNA was isolated from peripheral blood and genotyped by TaqMan. Results: Two loci significantly associated with obesity in Qataris: the TFAP2B variation (rs987237) (A allele versus G allele: chi-square = 10.3; P = 0.0013) and GNPDA2 variation (rs10938397) (A allele versus G allele: chi-square = 6.15; P = 0.013). The TFAP2B GG genotype negatively associated with obesity (OR = 0.21; P = 0.0031). Conversely, the GNDPA2 GG homozygous genotype associated with higher risk of obesity in subjects of age < 32 years (P = 0.0358). Conclusion: We showed a different genetic profile associated with obesity in the Qatari population compared to Western populations. Studying the genetic background of Qataris is of primary importance as the etiology of a given disease might be population-specific.

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