Obesity, diabetes and atrial fibrillation; epidemiology, mechanisms and interventions

O. Asghar, U. Alam, S. A. Hayat, R. Aghamohammadzadeh, A. M. Heagerty, Rayaz Malik

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

The last few decades have witnessed a global rise in adult obesity of epidemic proportions. The potential impact of this is emphasized when one considers that body mass index (BMI) is a powerful predictor of death, type 2 diabetes (T2DM) and cardiovascular (CV) morbidity and mortality [1, 2]. Similarly we have witnessed a parallel rise in the incidence of atrial fibrillation (AF), the commonest sustained cardiac arrhythmia, which is also a significant cause of cardiovascular morbidity and mortality. Part of this increase is attributable to advances in the treatment of coronary heart disease (CHD) and heart failure (HF) improving life expectancy and consequently the prevalence of AF. However, epidemiological studies have demonstrated an independent association between obesity and AF, possibly reflecting common pathophysiology and risk factors for both conditions. Indeed, weight gain and obesity are associated with structural and functional changes of the cardiovascular system including left atrial and ventricular remodeling, haemodynamic alterations, autonomic dysfunction, and diastolic dysfunction. Moreover, diabetic cardiomyopathy is characterized by an adverse structural and functional cardiac phenotype which may predispose to the development of AF [3]. In this review, we discuss the pathophysiological and mechanistic relationships between obesity, diabetes and AF, and the challenges posed in the management of this high-risk group of individuals.

Original languageEnglish
Pages (from-to)253-264
Number of pages12
JournalCurrent Cardiology Reviews
Volume8
Issue number4
DOIs
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Atrial Fibrillation
Epidemiology
Obesity
Diabetic Cardiomyopathies
Atrial Remodeling
Morbidity
Ventricular Remodeling
Mortality
Risk Management
Cardiovascular System
Life Expectancy
Type 2 Diabetes Mellitus
Weight Gain
Coronary Disease
Cardiac Arrhythmias
Epidemiologic Studies
Body Mass Index
Heart Failure
Hemodynamics
Phenotype

Keywords

  • Atrial fibrillation
  • Epidemiology
  • Metabolic syndrome
  • Morbidity
  • Mortality
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Obesity, diabetes and atrial fibrillation; epidemiology, mechanisms and interventions. / Asghar, O.; Alam, U.; Hayat, S. A.; Aghamohammadzadeh, R.; Heagerty, A. M.; Malik, Rayaz.

In: Current Cardiology Reviews, Vol. 8, No. 4, 2012, p. 253-264.

Research output: Contribution to journalReview article

Asghar, O. ; Alam, U. ; Hayat, S. A. ; Aghamohammadzadeh, R. ; Heagerty, A. M. ; Malik, Rayaz. / Obesity, diabetes and atrial fibrillation; epidemiology, mechanisms and interventions. In: Current Cardiology Reviews. 2012 ; Vol. 8, No. 4. pp. 253-264.
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