NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina

Essam Mohamed, Ikuo Tooyama

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Natriuretic peptide receptor C (NPR-C) is known to bind all natriuretic peptides with similar affinity. Given their biological role it is interesting that natriuretic peptides and their activated guanylate cyclases (NPR-A and NPR-B) are expressed in retinal amacrine cells. The purpose of this study is to examine the presence of NPR-C in the rat retina and its relationship to cholinergic and dopaminergic amacrine cells using immunofluorescence techniques. NPR-C immunoreactivity was found in several layers of the retina including the ganglion cell layer (GCL), inner nuclear layer (INL), outer plexiform layer (OPL), and inner segments of photoreceptors (IS). Immunofluorescence double-labeling showed the co-localization of NPR-C with tyrosine hydroxylase, a marker of dopaminergic cells, and with choline acetyltransferase (ChAT), a marker of cholinergic cells. These data suggest that natriuretic peptides may play a role in maintaining the retinal functions via interaction with NPR-C.

Original languageEnglish
Pages (from-to)180-183
Number of pages4
JournalPeptides
Volume31
Issue number1
DOIs
Publication statusPublished - 1 Jan 2010
Externally publishedYes

Fingerprint

Amacrine Cells
Natriuretic Peptides
Cholinergic Agents
Retina
Rats
Fluorescent Antibody Technique
Choline O-Acetyltransferase
Guanylate Cyclase
Tyrosine 3-Monooxygenase
Ganglia
Labeling
Cells
atrial natriuretic factor receptor C

Keywords

  • ACs
  • Choline acetyltransferase
  • Immunofluorescence
  • NPR-C
  • Retina
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina. / Mohamed, Essam; Tooyama, Ikuo.

In: Peptides, Vol. 31, No. 1, 01.01.2010, p. 180-183.

Research output: Contribution to journalArticle

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