Noninvasive prediction of organ graft rejection and outcome using gene expression patterns

Dany Anglicheau, Manikkam Suthanthiran

Research output: Contribution to journalReview article

68 Citations (Scopus)

Abstract

Development of predictive, diagnostic, and prognostic biomarkers of allograft status and outcome is important and challenging, and may be rewarded with individualized therapy for the organ graft recipient. Herein, we summarize noninvasive messenger RNA profiling studies for ascertaining allograft status and outcome. Nucleic acid-based biomarkers of allograft status have been developed by several laboratories, but the studies have primarily been single center investigations. Ongoing multicenter trials including the Clinical Trials in Organ Transplantation (https://www.ctotstudies.org) should help further to define the clinical utility of noninvasively developed messenger RNA profiles as biomarkers of allograft status and outcome.

Original languageEnglish
Pages (from-to)192-199
Number of pages8
JournalTransplantation
Volume86
Issue number2
DOIs
Publication statusPublished - 27 Jul 2008
Externally publishedYes

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Keywords

  • Biomarker
  • Diagnosis
  • Immune monitoring
  • mRNA
  • Transplantation

ASJC Scopus subject areas

  • Transplantation

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