Noninvasive diagnosis of acute rejection of solid organ transplants

Choli Hartono, Darshana Dadhania, Manikkam Suthanthiran

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Accurate diagnosis of acute rejection remains a formidable challenge in organ transplantation. The current gold standard diagnostic test for acute rejection is histological examination of the transplanted organ. However, biopsy procedures are invasive and complications occur. Furthermore, sampling errors may bias the histological diagnosis. Not uncommonly, empiric anti-rejection therapy has to be provided prior to the availability of a confirmatory histological report. Thus, there is an urgent need for specific and sensitive noninvasive biomarkers of acute rejection. Herein, we review noninvasive strategies for the diagnosis of acute rejection of solid organ transplants.

Original languageEnglish
Pages (from-to)145-153
Number of pages9
JournalFrontiers in Bioscience
Volume9
Publication statusPublished - 27 Jul 2004
Externally publishedYes

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Keywords

  • Heart
  • Immune system
  • Immunity
  • Kidney
  • Liver
  • Lung
  • mRNA
  • Rejection
  • Review
  • Transplant
  • Transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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