Non-selective voltage-activated cation channel in the human red blood cell membrane

Lars Kaestner, Christian Bollensdorff, Ingolf Bernhardt

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50 Citations (Scopus)

Abstract

Using the patch-clamp technique, a non-selective voltage-activated Na+ and K+ channel in the human red blood cell membrane was found. The channel operates only at positive membrane potentials from about +30 mV (inside positive) onwards. For sodium and potassium ions, similar conductances of about 21 pS were determined. Together with the recently described K+(Na+)/H+ exchanger, this channel is responsible for the increase of residual K+ and Na+ fluxes across the human red blood cell membrane when the cells are suspended in low ionic strength medium. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1417
Issue number1
DOIs
Publication statusPublished - 4 Feb 1999
Externally publishedYes

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Keywords

  • Cation channel
  • Erythrocyte
  • Low ionic strength
  • Patch clamp
  • Residual transport

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biophysics

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