Non-selective voltage-activated cation channel in the human red blood cell membrane

Lars Kaestner, Christian Bollensdorff, Ingolf Bernhardt

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Using the patch-clamp technique, a non-selective voltage-activated Na+ and K+ channel in the human red blood cell membrane was found. The channel operates only at positive membrane potentials from about +30 mV (inside positive) onwards. For sodium and potassium ions, similar conductances of about 21 pS were determined. Together with the recently described K+(Na+)/H+ exchanger, this channel is responsible for the increase of residual K+ and Na+ fluxes across the human red blood cell membrane when the cells are suspended in low ionic strength medium. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)9-15
Number of pages7
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1417
Issue number1
DOIs
Publication statusPublished - 4 Feb 1999
Externally publishedYes

Fingerprint

Cell membranes
Potassium-Hydrogen Antiporters
Cations
Blood
Erythrocytes
Cell Membrane
Sodium-Hydrogen Antiporter
Clamping devices
Electric potential
Patch-Clamp Techniques
Ionic strength
Membrane Potentials
Osmolar Concentration
Potassium
Sodium
Ions
Fluxes
Membranes

Keywords

  • Cation channel
  • Erythrocyte
  • Low ionic strength
  • Patch clamp
  • Residual transport

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biophysics

Cite this

Non-selective voltage-activated cation channel in the human red blood cell membrane. / Kaestner, Lars; Bollensdorff, Christian; Bernhardt, Ingolf.

In: Biochimica et Biophysica Acta - Biomembranes, Vol. 1417, No. 1, 04.02.1999, p. 9-15.

Research output: Contribution to journalArticle

Kaestner, Lars ; Bollensdorff, Christian ; Bernhardt, Ingolf. / Non-selective voltage-activated cation channel in the human red blood cell membrane. In: Biochimica et Biophysica Acta - Biomembranes. 1999 ; Vol. 1417, No. 1. pp. 9-15.
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