Ni1-xCrx alloy for self controlled magnetic hyperthermia

Y. Akin, I. M. Obaidat, B. Issa, Yousef Haik

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

It is known now that an increase in tumor temperature decreases the tumor resistance to chemo- and radiation therapies. Hyperthermia treatment of the tumor cells where damage to the healthy cells can be avoided is viable by using magnetic nanoparticles with controlled Curie temperatures. Nickel-Chromium (NiK1-xCrx) particles with varying compositions have been investigated as thermoseeds for use in localized self controlled hyperthermia treatment of cancer. A series of Ni1-xCrx alloys, have been prepared to find the specific composition which has Curie temperature around 316-317 K. The samples were cast by arc melting technique, and were annealed at 850 °C for 5 hours in sealed quartz tubes. Magnetic properties of the samples were investigated, including Curie temperature, saturation magnetization and hysterisis using Superconducting Quantum Interference Device (SQUID) and Vibrating Sample Magnetometer (VSM). The Curie temperatures of the alloys were found to decrease almost linearly from 401 K to 289 K as the Cr concentration was increased from x = 4.54 wt % to x = 5.90 wt %. The results showed that Ni1-xCr, alloys might be good candidates for self regulating magnetic hyperthermia applications.

Original languageEnglish
Pages (from-to)386-390
Number of pages5
JournalCrystal Research and Technology
Volume44
Issue number4
DOIs
Publication statusPublished - Apr 2009
Externally publishedYes

Fingerprint

hyperthermia
Curie temperature
Tumors
tumors
Cells
arc melting
automatic control
Quartz
Chemotherapy
SQUIDs
Radiotherapy
Chromium
Magnetometers
Saturation magnetization
chemotherapy
Nickel
Chemical analysis
magnetometers
casts
radiation therapy

Keywords

  • Curie temperature
  • Magnetic hyperthermia
  • Nickel-chromium particles

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Ni1-xCrx alloy for self controlled magnetic hyperthermia. / Akin, Y.; Obaidat, I. M.; Issa, B.; Haik, Yousef.

In: Crystal Research and Technology, Vol. 44, No. 4, 04.2009, p. 386-390.

Research output: Contribution to journalArticle

Akin, Y. ; Obaidat, I. M. ; Issa, B. ; Haik, Yousef. / Ni1-xCrx alloy for self controlled magnetic hyperthermia. In: Crystal Research and Technology. 2009 ; Vol. 44, No. 4. pp. 386-390.
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