Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours

Glen H. Hall, Lindsay W. Turnbull, Karen Bedford, Ian Richmond, Lone Helboe, Stephen L. Atkin

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Vascular endothelial growth factor (VEGF), is an angiogenic growth factor, expressed more highly in malignant than benign ovarian tumours. Neuropilin-1, which can act as a VEGF receptor has been shown to be associated with tumour angiogenesis in some cancer systems. Somatostatin (SST), a potentially anti-angiogenic factor, acts via somatostatin receptors that are expressed in ovarian cancer. We used immunohistochemistry to demonstrate expression of Neuropilin-1 in 63 malignant and 35 benign ovarian tumours and compared it to VEGF, Fit, Fik, SST expression and tumour microvessel density (MVD). Neuropilin-1 was expressed in 34/63 malignant and 22/35 benign lesions. VEGF, Fit, Flk and SST were expressed more highly in the epithelium of malignant and the vessels of benign lesions. VEGF expression correlated with SST expression in the epithelium (p<0.001) and the vessels (p<0.001), this co-expression was confirmed by dual immunostaining. The MVD for malignant lesions was higher than benign (p<0.001) and positively correlated to epithelial VEGF expression (p=0.001) and negatively correlated to vascular VEGF expression (p=0.025). These results show that Neuropilin-1 is expressed in ovarian tumours and also show that VEGF and SST are co-expressed in the same tissue compartments raising the intriguing possibility that SST may be important in angiogenesis in ovarian cancer.

Original languageEnglish
Pages (from-to)1283-1288
Number of pages6
JournalInternational Journal of Oncology
Volume27
Issue number5
Publication statusPublished - Nov 2005
Externally publishedYes

Fingerprint

Neuropilin-1
Microvessels
Somatostatin
Vascular Endothelial Growth Factor A
Neoplasms
Angiogenesis Inducing Agents
Ovarian Neoplasms
Epithelium
Somatostatin Receptors
Vascular Endothelial Growth Factor Receptor
Blood Vessels
Intercellular Signaling Peptides and Proteins
Immunohistochemistry

Keywords

  • Angiogenesis
  • Neuropilin-1
  • Ovarian cancer
  • Somatostatin
  • Somatostatin receptors
  • VEGF

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours. / Hall, Glen H.; Turnbull, Lindsay W.; Bedford, Karen; Richmond, Ian; Helboe, Lone; Atkin, Stephen L.

In: International Journal of Oncology, Vol. 27, No. 5, 11.2005, p. 1283-1288.

Research output: Contribution to journalArticle

Hall, GH, Turnbull, LW, Bedford, K, Richmond, I, Helboe, L & Atkin, SL 2005, 'Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours', International Journal of Oncology, vol. 27, no. 5, pp. 1283-1288.
Hall, Glen H. ; Turnbull, Lindsay W. ; Bedford, Karen ; Richmond, Ian ; Helboe, Lone ; Atkin, Stephen L. / Neuropilin-1 and VEGF correlate with somatostatin expression and microvessel density in ovarian tumours. In: International Journal of Oncology. 2005 ; Vol. 27, No. 5. pp. 1283-1288.
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