NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy

Georgios Ponirakis, M. N. Odriozola, S. Odriozola, I. N. Petropoulos, S. Azmi, H. Fadavi, U. Alam, O. Asghar, A. Marshall, A. Miro, A. Kheyami, A. Al-Ahmar, M. B. Odriozola, A. Odriozola, Rayaz Malik

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aims: Sensory neuropathy is central to the development of painful neuropathy, and foot ulceration in patients with diabetes. Currently, available QST devices take considerable time to perform and are expensive. NerveCheck is the first inexpensive ($500), portable QST device to perform both vibration and thermal testing and hence evaluate diabetic peripheral neuropathy (DPN). This study was undertaken to establish the reproducibility and diagnostic validity of NerveCheck for detecting neuropathy. Methods: 130 subjects (28 with DPN, 46 without DPN and 56 control subjects) underwent QST assessment with NerveCheck; vibration perception and thermal testing. DPN was defined according to the Toronto criteria. Results: NerveCheck's intra correlation coefficient for vibration, cold and warm sensation testing was 0.79 (95% LOA: -4.20 to 6.60), 0.86 (95% LOA: -1.38 to 2.72) and 0.71 (95% LOA: -2.36 to 3.83), respectively. The diagnostic accuracy (AUC) for vibration, cold and warm sensation testing was 86% (SE: 0.038, 95% CI 0.79-0.94), 79% (SE: 0.058, 95% CI 0.68-0.91) and 72% (SE: 0.058, 95% CI 0.60-0.83), respectively. Conclusions: This study shows that NerveCheck has good reproducibility and comparable diagnostic accuracy to established QST equipment for the diagnosis of DPN.

Original languageEnglish
Pages (from-to)101-107
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume113
DOIs
Publication statusPublished - 1 Mar 2016

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Diabetic Neuropathies
Peripheral Nervous System Diseases
Vibration
Equipment and Supplies
Hot Temperature
Foot

Keywords

  • Diabetes
  • Diagnostic device
  • NerveCheck
  • Neuropathy
  • Quantitative sensory testing

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

NerveCheck : An inexpensive quantitative sensory testing device for patients with diabetic neuropathy. / Ponirakis, Georgios; Odriozola, M. N.; Odriozola, S.; Petropoulos, I. N.; Azmi, S.; Fadavi, H.; Alam, U.; Asghar, O.; Marshall, A.; Miro, A.; Kheyami, A.; Al-Ahmar, A.; Odriozola, M. B.; Odriozola, A.; Malik, Rayaz.

In: Diabetes Research and Clinical Practice, Vol. 113, 01.03.2016, p. 101-107.

Research output: Contribution to journalArticle

Ponirakis, G, Odriozola, MN, Odriozola, S, Petropoulos, IN, Azmi, S, Fadavi, H, Alam, U, Asghar, O, Marshall, A, Miro, A, Kheyami, A, Al-Ahmar, A, Odriozola, MB, Odriozola, A & Malik, R 2016, 'NerveCheck: An inexpensive quantitative sensory testing device for patients with diabetic neuropathy', Diabetes Research and Clinical Practice, vol. 113, pp. 101-107. https://doi.org/10.1016/j.diabres.2015.12.023
Ponirakis, Georgios ; Odriozola, M. N. ; Odriozola, S. ; Petropoulos, I. N. ; Azmi, S. ; Fadavi, H. ; Alam, U. ; Asghar, O. ; Marshall, A. ; Miro, A. ; Kheyami, A. ; Al-Ahmar, A. ; Odriozola, M. B. ; Odriozola, A. ; Malik, Rayaz. / NerveCheck : An inexpensive quantitative sensory testing device for patients with diabetic neuropathy. In: Diabetes Research and Clinical Practice. 2016 ; Vol. 113. pp. 101-107.
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AU - Petropoulos, I. N.

AU - Azmi, S.

AU - Fadavi, H.

AU - Alam, U.

AU - Asghar, O.

AU - Marshall, A.

AU - Miro, A.

AU - Kheyami, A.

AU - Al-Ahmar, A.

AU - Odriozola, M. B.

AU - Odriozola, A.

AU - Malik, Rayaz

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N2 - Aims: Sensory neuropathy is central to the development of painful neuropathy, and foot ulceration in patients with diabetes. Currently, available QST devices take considerable time to perform and are expensive. NerveCheck is the first inexpensive ($500), portable QST device to perform both vibration and thermal testing and hence evaluate diabetic peripheral neuropathy (DPN). This study was undertaken to establish the reproducibility and diagnostic validity of NerveCheck for detecting neuropathy. Methods: 130 subjects (28 with DPN, 46 without DPN and 56 control subjects) underwent QST assessment with NerveCheck; vibration perception and thermal testing. DPN was defined according to the Toronto criteria. Results: NerveCheck's intra correlation coefficient for vibration, cold and warm sensation testing was 0.79 (95% LOA: -4.20 to 6.60), 0.86 (95% LOA: -1.38 to 2.72) and 0.71 (95% LOA: -2.36 to 3.83), respectively. The diagnostic accuracy (AUC) for vibration, cold and warm sensation testing was 86% (SE: 0.038, 95% CI 0.79-0.94), 79% (SE: 0.058, 95% CI 0.68-0.91) and 72% (SE: 0.058, 95% CI 0.60-0.83), respectively. Conclusions: This study shows that NerveCheck has good reproducibility and comparable diagnostic accuracy to established QST equipment for the diagnosis of DPN.

AB - Aims: Sensory neuropathy is central to the development of painful neuropathy, and foot ulceration in patients with diabetes. Currently, available QST devices take considerable time to perform and are expensive. NerveCheck is the first inexpensive ($500), portable QST device to perform both vibration and thermal testing and hence evaluate diabetic peripheral neuropathy (DPN). This study was undertaken to establish the reproducibility and diagnostic validity of NerveCheck for detecting neuropathy. Methods: 130 subjects (28 with DPN, 46 without DPN and 56 control subjects) underwent QST assessment with NerveCheck; vibration perception and thermal testing. DPN was defined according to the Toronto criteria. Results: NerveCheck's intra correlation coefficient for vibration, cold and warm sensation testing was 0.79 (95% LOA: -4.20 to 6.60), 0.86 (95% LOA: -1.38 to 2.72) and 0.71 (95% LOA: -2.36 to 3.83), respectively. The diagnostic accuracy (AUC) for vibration, cold and warm sensation testing was 86% (SE: 0.038, 95% CI 0.79-0.94), 79% (SE: 0.058, 95% CI 0.68-0.91) and 72% (SE: 0.058, 95% CI 0.60-0.83), respectively. Conclusions: This study shows that NerveCheck has good reproducibility and comparable diagnostic accuracy to established QST equipment for the diagnosis of DPN.

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