Nerve pathology in the type 1 diabetic dog

Effects of treatment with sulindac

David Walker, Irfan Siddique, Heather Anderson, Tom A. Gardiner, Desmond B. Archer, Andrew J M Boulton, Rayaz Malik

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The purpose of this study was to define pathological abnormalities in the peripheral nerve of a large animal model of long-duration type 1 diabetes and also to determine the effects of treatment with sulindac. Detailed morphometric studies were performed to define nerve fiber and endoneurial capillary pathology in 6 control dogs, 6 type 1 diabetic dogs treated with insulin, and 6 type 1 diabetic dogs treated with insulin and sulindac for 4 years. Myelinated fiber and regenerative cluster density showed a non-significant trend toward a reduction in diabetic compared to control animals, which was prevented by treatment with sulindac. Unmyelinated fiber density did not differ among groups. However, diabetic animals showed a non-significant trend toward an increase in axon diameter (p < 0.07), with a shift of the size frequency distribution towards larger axons, which was not prevented by treatment with sulindac. Endoneurial capillary density and luminal area showed a non-significant trend toward an increase in diabetic animals, which was prevented with sulindac treatment. Endoneurial capillary basement membrane area was significantly increased (p < 0.05) in diabetic animals, but was not prevented with sulindac treatment. We conclude that the type 1 diabetic dog demonstrates minor structural abnormalities in the nerve fibers and endoneurial capillaries of the sciatic nerve, and treatment with sulindac ameliorates some but not all of these abnormalities.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalJournal of the Peripheral Nervous System
Volume6
Issue number4
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Sulindac
Dogs
Pathology
Nerve Fibers
Axons
Insulin
Sciatic Nerve
Type 1 Diabetes Mellitus
Peripheral Nerves
Basement Membrane
Animal Models

Keywords

  • Endoneurial capillary
  • Morphometry
  • Nerve fiber
  • Neuropathy
  • Sulindac
  • Type 1 diabetes

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Nerve pathology in the type 1 diabetic dog : Effects of treatment with sulindac. / Walker, David; Siddique, Irfan; Anderson, Heather; Gardiner, Tom A.; Archer, Desmond B.; Boulton, Andrew J M; Malik, Rayaz.

In: Journal of the Peripheral Nervous System, Vol. 6, No. 4, 2001, p. 219-226.

Research output: Contribution to journalArticle

Walker, David ; Siddique, Irfan ; Anderson, Heather ; Gardiner, Tom A. ; Archer, Desmond B. ; Boulton, Andrew J M ; Malik, Rayaz. / Nerve pathology in the type 1 diabetic dog : Effects of treatment with sulindac. In: Journal of the Peripheral Nervous System. 2001 ; Vol. 6, No. 4. pp. 219-226.
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