Natural history of cadaveric kidney transplants in the absence of early acute rejection

J. S. Cheigh, S. D. Saal, Manikkam Suthanthiran, R. R. Riggio, M. Fotino, W. T. Stubenbord, K. H. Stenzel, A. L. Rubin

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The foremost goal in organ transplantation is to achieve normal graft function without rejection. 31 (8.7%) of 357 cadaveric kidney transplants had no evidence of rejection for the first 3 months. Among these, 2 patients died with a functioning graft and four grafts failed during the 1- to 7-year follow-up period. Actuarial graft survival rates of these patients were 96.8 and 79.0% at 2 and 5 years, respectively, as compared with 64.6 and 51.2%, respectively, for the controls (p < 0.01). Multiple preoperative blood transfusions and the adjunctive immunosuppressive therapy with retroplacental gamma globulin appeared to be playing a role for the induction of the 'no-rejection' state. However, continuous immunosuppressive therapy is necessary to maintain graft function.

Original languageEnglish
Pages (from-to)6-10
Number of pages5
JournalNephron
Volume35
Issue number1
Publication statusPublished - 1 Sep 1983
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Nephrology

Cite this

Cheigh, J. S., Saal, S. D., Suthanthiran, M., Riggio, R. R., Fotino, M., Stubenbord, W. T., Stenzel, K. H., & Rubin, A. L. (1983). Natural history of cadaveric kidney transplants in the absence of early acute rejection. Nephron, 35(1), 6-10.