Natural compounds with DPP-4 inhibitory effects: Implications for the treatment of diabetes

Habib Yaribeygi, Stephen Atkin, Amirhossein Sahebkar

Research output: Contribution to journalReview article

2 Citations (Scopus)


Dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetes agents that decrease blood glucose by preventing the degradation of endogenous glucagon-like peptide-1. The first DPP-4 was sitagliptin followed by several other agents in the class introduced to manage diabetes. Recent studies have suggested that naturally occurring compounds can exert an antidiabetes effect through DPP-4 inhibition. Such compounds may have a place in the treatment of diabetes within the diet; however, while DPP-4 inhibition alone is not associated with hypoglycemia, in combinations with other medication hypoglycemia can result, therefore, it is critical to know what herbal or food-based compounds may have these activities in the management of diabetes patients. In this review, we have outlined the compounds that have DPP-4 inhibition that may have utility in the treatment of diabetes.

Original languageEnglish
JournalJournal of Cellular Biochemistry
Publication statusPublished - 1 Jan 2019



  • alkaloids
  • diabetes mellitus
  • dipeptidyl peptidase-4 inhibitors
  • glycosides
  • herbal compounds
  • phenol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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