NAADP as an intracellular messenger regulating lysosomal calcium-release channels

Antony Galione, Anthony J. Morgan, Abdelilah Arredouani, Lianne C. Davis, Katja Rietdorf, Margarida Ruas, John Parrington

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Recent studies into the mechanisms of action of the Ca2+- mobilizing messenger NAADP (nicotinic acid-adenine dinucleotide phosphate) have demonstrated that a novel family of intracellular Ca2+-release channels termed TPCs (two-pore channels) are components of the NAADP receptor. TPCs appear to be exclusively localized to the endolysosomal system. These findings confirm previous pharmacological and biochemical studies suggesting that NAADP targets acidic Ca2+ stores rather than the endoplasmic reticulum, the major site of action of the other two principal Ca 2+-mobilizing messengers, InsP3 and cADPR (cADP-ribose). Studies of the messenger roles of NAADP and the function of TPCs highlight the novel role of lysosomes and other organelles of the endocytic pathway as messenger-regulated Ca2+ stores which also affects the regulation of the endolysosomal system.

Original languageEnglish
Pages (from-to)1424-1431
Number of pages8
JournalBiochemical Society Transactions
Issue number6
Publication statusPublished - 1 Dec 2010



  • Calcium-release channel
  • Endolysosomal system
  • Lysosome
  • Nicotinic acid-adenine dinucleotide phosphate (NAADP)
  • Two-pore channel (TPC)

ASJC Scopus subject areas

  • Biochemistry

Cite this

Galione, A., Morgan, A. J., Arredouani, A., Davis, L. C., Rietdorf, K., Ruas, M., & Parrington, J. (2010). NAADP as an intracellular messenger regulating lysosomal calcium-release channels. Biochemical Society Transactions, 38(6), 1424-1431.