N-terminal pro-brain natriuretic peptide and abnormal brain aging

Behnam Sabayan, Mark A. Van Buchem, Anton J M De Craen, Sigurdur Sigurdsson, Qian Zhang, Tamara B. Harris, Vilmundur Gudnason, Andrew E. Arai, Lenore J. Launer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To investigate the independent association of serum N-terminal fragment of the prohormone natriuretic peptide (NT-proBNP) with structural and functional features of abnormal brain aging in older individuals. Methods: In this cross-sectional study based on the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we included 4,029 older community-dwelling individuals (born 1907 to 1935) with a measured serum level of NT-proBNP. Outcomes included parenchymal brain volumes estimated from brain MRI, cognitive function measured by tests of memory, processing speed, and executive functioning, and presence of depressive symptoms measured using the Geriatric Depression Scale. In a substudy, cardiac output of 857 participants was assessed using cardiac MRI. Results: In multivariate analyses, adjusted for sociodemographic and cardiovascular factors, higher levels of NT-proBNP were independently associated with lower total (p < 0.001), gray matter (p < 0.001), and white matter (p 0.001) brain volumes. Likewise, in multivariate analyses, higher levels of NT-proBNP were associated with worse scores in memory (p 0.005), processing speed (p 0.001), executive functioning (p < 0.001), and more depressive symptoms (p 0.002). In the substudy, the associations of higher NT-proBNP with lower brain parenchymal volumes, impaired executive function and processing speed, and higher depressive symptoms were independent of the level of cardiac output. Conclusions: Higher serum levels of NT-proBNP, independent of cardiovascular risk factors and a measure of cardiac function, are linked with alterations in brain structure and function. Roles of natriuretic peptides in the process of brain aging need to be further elucidated.

Original languageEnglish
Pages (from-to)813-820
Number of pages8
JournalNeurology
Volume85
Issue number9
DOIs
Publication statusPublished - 1 Sep 2015
Externally publishedYes

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Brain Natriuretic Peptide
Brain
Depression
Natriuretic Peptides
Cardiac Output
Multivariate Analysis
Serum
Independent Living
Executive Function
Geriatrics
Cognition
pro-brain natriuretic peptide (1-76)
Cross-Sectional Studies
Genes

ASJC Scopus subject areas

  • Clinical Neurology
  • Medicine(all)

Cite this

Sabayan, B., Van Buchem, M. A., De Craen, A. J. M., Sigurdsson, S., Zhang, Q., Harris, T. B., ... Launer, L. J. (2015). N-terminal pro-brain natriuretic peptide and abnormal brain aging. Neurology, 85(9), 813-820. https://doi.org/10.1212/WNL.0000000000001885

N-terminal pro-brain natriuretic peptide and abnormal brain aging. / Sabayan, Behnam; Van Buchem, Mark A.; De Craen, Anton J M; Sigurdsson, Sigurdur; Zhang, Qian; Harris, Tamara B.; Gudnason, Vilmundur; Arai, Andrew E.; Launer, Lenore J.

In: Neurology, Vol. 85, No. 9, 01.09.2015, p. 813-820.

Research output: Contribution to journalArticle

Sabayan, B, Van Buchem, MA, De Craen, AJM, Sigurdsson, S, Zhang, Q, Harris, TB, Gudnason, V, Arai, AE & Launer, LJ 2015, 'N-terminal pro-brain natriuretic peptide and abnormal brain aging', Neurology, vol. 85, no. 9, pp. 813-820. https://doi.org/10.1212/WNL.0000000000001885
Sabayan B, Van Buchem MA, De Craen AJM, Sigurdsson S, Zhang Q, Harris TB et al. N-terminal pro-brain natriuretic peptide and abnormal brain aging. Neurology. 2015 Sep 1;85(9):813-820. https://doi.org/10.1212/WNL.0000000000001885
Sabayan, Behnam ; Van Buchem, Mark A. ; De Craen, Anton J M ; Sigurdsson, Sigurdur ; Zhang, Qian ; Harris, Tamara B. ; Gudnason, Vilmundur ; Arai, Andrew E. ; Launer, Lenore J. / N-terminal pro-brain natriuretic peptide and abnormal brain aging. In: Neurology. 2015 ; Vol. 85, No. 9. pp. 813-820.
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AB - Objective: To investigate the independent association of serum N-terminal fragment of the prohormone natriuretic peptide (NT-proBNP) with structural and functional features of abnormal brain aging in older individuals. Methods: In this cross-sectional study based on the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we included 4,029 older community-dwelling individuals (born 1907 to 1935) with a measured serum level of NT-proBNP. Outcomes included parenchymal brain volumes estimated from brain MRI, cognitive function measured by tests of memory, processing speed, and executive functioning, and presence of depressive symptoms measured using the Geriatric Depression Scale. In a substudy, cardiac output of 857 participants was assessed using cardiac MRI. Results: In multivariate analyses, adjusted for sociodemographic and cardiovascular factors, higher levels of NT-proBNP were independently associated with lower total (p < 0.001), gray matter (p < 0.001), and white matter (p 0.001) brain volumes. Likewise, in multivariate analyses, higher levels of NT-proBNP were associated with worse scores in memory (p 0.005), processing speed (p 0.001), executive functioning (p < 0.001), and more depressive symptoms (p 0.002). In the substudy, the associations of higher NT-proBNP with lower brain parenchymal volumes, impaired executive function and processing speed, and higher depressive symptoms were independent of the level of cardiac output. Conclusions: Higher serum levels of NT-proBNP, independent of cardiovascular risk factors and a measure of cardiac function, are linked with alterations in brain structure and function. Roles of natriuretic peptides in the process of brain aging need to be further elucidated.

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