Myokymia and impaired muscular relaxation with continuous motor unit activity

F. D. Lublin, P. Tsairis, Leopold Streletz, R. A. Chambers, W. F. Riker, A. Van Poznak, S. W. Duckett

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The authors have studied two cases of the syndrome of myokymia and impaired muscular relaxation with continuous motor unit activity. Both patients complained of muscle twitching, weakness, stiffness, and hyperhidrosis during their illness. Myokymia was present over the entire body in both. On repetitive testing of muscle strength each patient showed initial fatigue followed by increasing strength as he continued his efforts. Both patients improved on phenytoin therapy at high blood levels. Nerve conduction velocities were decreased. Electromyograms showed continuous electrical activity at rest which persisted during sleep and spinal anaesthesia but was diminished by curare. Intravital staining with methylene blue in one case demonstrated sprouting and beading of motor nerve terminals with multiple innervation of muscle fibres. The neurophysiological and pathological findings in these two cases indicate an abnormality of peripheral nerve in this disorder.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume42
Issue number6
Publication statusPublished - 1979
Externally publishedYes

Fingerprint

Myokymia
Motor Activity
Curare
Hyperhidrosis
Spinal Anesthesia
Methylene Blue
Neural Conduction
Muscle Weakness
Phenytoin
Muscle Strength
Electromyography
Peripheral Nerves
Fatigue
Sleep
Staining and Labeling
Muscles
Therapeutics

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Lublin, F. D., Tsairis, P., Streletz, L., Chambers, R. A., Riker, W. F., Van Poznak, A., & Duckett, S. W. (1979). Myokymia and impaired muscular relaxation with continuous motor unit activity. Journal of Neurology Neurosurgery and Psychiatry, 42(6), 557-562.

Myokymia and impaired muscular relaxation with continuous motor unit activity. / Lublin, F. D.; Tsairis, P.; Streletz, Leopold; Chambers, R. A.; Riker, W. F.; Van Poznak, A.; Duckett, S. W.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 42, No. 6, 1979, p. 557-562.

Research output: Contribution to journalArticle

Lublin, FD, Tsairis, P, Streletz, L, Chambers, RA, Riker, WF, Van Poznak, A & Duckett, SW 1979, 'Myokymia and impaired muscular relaxation with continuous motor unit activity', Journal of Neurology Neurosurgery and Psychiatry, vol. 42, no. 6, pp. 557-562.
Lublin, F. D. ; Tsairis, P. ; Streletz, Leopold ; Chambers, R. A. ; Riker, W. F. ; Van Poznak, A. ; Duckett, S. W. / Myokymia and impaired muscular relaxation with continuous motor unit activity. In: Journal of Neurology Neurosurgery and Psychiatry. 1979 ; Vol. 42, No. 6. pp. 557-562.
@article{cd5ee4ed6a83408ea1468af415d7db1a,
title = "Myokymia and impaired muscular relaxation with continuous motor unit activity",
abstract = "The authors have studied two cases of the syndrome of myokymia and impaired muscular relaxation with continuous motor unit activity. Both patients complained of muscle twitching, weakness, stiffness, and hyperhidrosis during their illness. Myokymia was present over the entire body in both. On repetitive testing of muscle strength each patient showed initial fatigue followed by increasing strength as he continued his efforts. Both patients improved on phenytoin therapy at high blood levels. Nerve conduction velocities were decreased. Electromyograms showed continuous electrical activity at rest which persisted during sleep and spinal anaesthesia but was diminished by curare. Intravital staining with methylene blue in one case demonstrated sprouting and beading of motor nerve terminals with multiple innervation of muscle fibres. The neurophysiological and pathological findings in these two cases indicate an abnormality of peripheral nerve in this disorder.",
author = "Lublin, {F. D.} and P. Tsairis and Leopold Streletz and Chambers, {R. A.} and Riker, {W. F.} and {Van Poznak}, A. and Duckett, {S. W.}",
year = "1979",
language = "English",
volume = "42",
pages = "557--562",
journal = "Journal of Neurology, Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "6",

}

TY - JOUR

T1 - Myokymia and impaired muscular relaxation with continuous motor unit activity

AU - Lublin, F. D.

AU - Tsairis, P.

AU - Streletz, Leopold

AU - Chambers, R. A.

AU - Riker, W. F.

AU - Van Poznak, A.

AU - Duckett, S. W.

PY - 1979

Y1 - 1979

N2 - The authors have studied two cases of the syndrome of myokymia and impaired muscular relaxation with continuous motor unit activity. Both patients complained of muscle twitching, weakness, stiffness, and hyperhidrosis during their illness. Myokymia was present over the entire body in both. On repetitive testing of muscle strength each patient showed initial fatigue followed by increasing strength as he continued his efforts. Both patients improved on phenytoin therapy at high blood levels. Nerve conduction velocities were decreased. Electromyograms showed continuous electrical activity at rest which persisted during sleep and spinal anaesthesia but was diminished by curare. Intravital staining with methylene blue in one case demonstrated sprouting and beading of motor nerve terminals with multiple innervation of muscle fibres. The neurophysiological and pathological findings in these two cases indicate an abnormality of peripheral nerve in this disorder.

AB - The authors have studied two cases of the syndrome of myokymia and impaired muscular relaxation with continuous motor unit activity. Both patients complained of muscle twitching, weakness, stiffness, and hyperhidrosis during their illness. Myokymia was present over the entire body in both. On repetitive testing of muscle strength each patient showed initial fatigue followed by increasing strength as he continued his efforts. Both patients improved on phenytoin therapy at high blood levels. Nerve conduction velocities were decreased. Electromyograms showed continuous electrical activity at rest which persisted during sleep and spinal anaesthesia but was diminished by curare. Intravital staining with methylene blue in one case demonstrated sprouting and beading of motor nerve terminals with multiple innervation of muscle fibres. The neurophysiological and pathological findings in these two cases indicate an abnormality of peripheral nerve in this disorder.

UR - http://www.scopus.com/inward/record.url?scp=0018346327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018346327&partnerID=8YFLogxK

M3 - Article

VL - 42

SP - 557

EP - 562

JO - Journal of Neurology, Neurosurgery and Psychiatry

JF - Journal of Neurology, Neurosurgery and Psychiatry

SN - 0022-3050

IS - 6

ER -