Myokymia and impaired muscular relaxation with continuous motor unit activity

F. D. Lublin, P. Tsairis, Leopold Streletz, R. A. Chambers, W. F. Riker, A. Van Poznak, S. W. Duckett

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Abstract

The authors have studied two cases of the syndrome of myokymia and impaired muscular relaxation with continuous motor unit activity. Both patients complained of muscle twitching, weakness, stiffness, and hyperhidrosis during their illness. Myokymia was present over the entire body in both. On repetitive testing of muscle strength each patient showed initial fatigue followed by increasing strength as he continued his efforts. Both patients improved on phenytoin therapy at high blood levels. Nerve conduction velocities were decreased. Electromyograms showed continuous electrical activity at rest which persisted during sleep and spinal anaesthesia but was diminished by curare. Intravital staining with methylene blue in one case demonstrated sprouting and beading of motor nerve terminals with multiple innervation of muscle fibres. The neurophysiological and pathological findings in these two cases indicate an abnormality of peripheral nerve in this disorder.

Original languageEnglish
Pages (from-to)557-562
Number of pages6
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume42
Issue number6
Publication statusPublished - 1979
Externally publishedYes

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ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Lublin, F. D., Tsairis, P., Streletz, L., Chambers, R. A., Riker, W. F., Van Poznak, A., & Duckett, S. W. (1979). Myokymia and impaired muscular relaxation with continuous motor unit activity. Journal of Neurology Neurosurgery and Psychiatry, 42(6), 557-562.