Myofilament length dependent activation

Pieter P. de Tombe, Ryan D. Mateja, Kittipong Tachampa, Younss Ait Mou, Gerrie P. Farman, Thomas C. Irving

Research output: Contribution to journalArticle

139 Citations (Scopus)

Abstract

The Frank-Starling law of the heart describes the interrelationship between end-diastolic volume and cardiac ejection volume, a regulatory system that operates on a beat-to-beat basis. The main cellular mechanism that underlies this phenomenon is an increase in the responsiveness of cardiac myofilaments to activating Ca2+ ions at a longer sarcomere length, commonly referred to as myofilament length-dependent activation. This review focuses on what molecular mechanisms may underlie myofilament length dependency. Specifically, the roles of inter-filament spacing, thick and thin filament based regulation, as well as sarcomeric regulatory proteins are discussed. Although the "Frank-Starling law of the heart" constitutes a fundamental cardiac property that has been appreciated for well over a century, it is still not known in muscle how the contractile apparatus transduces the information concerning sarcomere length to modulate ventricular pressure development.

Original languageEnglish
Pages (from-to)851-858
Number of pages8
JournalJournal of Molecular and Cellular Cardiology
Volume48
Issue number5
DOIs
Publication statusPublished - 1 May 2010
Externally publishedYes

Fingerprint

Myofibrils
Starlings
Sarcomeres
Cardiac Volume
Ventricular Pressure
Ions
Muscles
Proteins

Keywords

  • Frank-Starling Law of The Heart
  • Length-Tension Relationship
  • Regulation
  • Sarcomere length

ASJC Scopus subject areas

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

de Tombe, P. P., Mateja, R. D., Tachampa, K., Mou, Y. A., Farman, G. P., & Irving, T. C. (2010). Myofilament length dependent activation. Journal of Molecular and Cellular Cardiology, 48(5), 851-858. https://doi.org/10.1016/j.yjmcc.2009.12.017

Myofilament length dependent activation. / de Tombe, Pieter P.; Mateja, Ryan D.; Tachampa, Kittipong; Mou, Younss Ait; Farman, Gerrie P.; Irving, Thomas C.

In: Journal of Molecular and Cellular Cardiology, Vol. 48, No. 5, 01.05.2010, p. 851-858.

Research output: Contribution to journalArticle

de Tombe, PP, Mateja, RD, Tachampa, K, Mou, YA, Farman, GP & Irving, TC 2010, 'Myofilament length dependent activation', Journal of Molecular and Cellular Cardiology, vol. 48, no. 5, pp. 851-858. https://doi.org/10.1016/j.yjmcc.2009.12.017
de Tombe PP, Mateja RD, Tachampa K, Mou YA, Farman GP, Irving TC. Myofilament length dependent activation. Journal of Molecular and Cellular Cardiology. 2010 May 1;48(5):851-858. https://doi.org/10.1016/j.yjmcc.2009.12.017
de Tombe, Pieter P. ; Mateja, Ryan D. ; Tachampa, Kittipong ; Mou, Younss Ait ; Farman, Gerrie P. ; Irving, Thomas C. / Myofilament length dependent activation. In: Journal of Molecular and Cellular Cardiology. 2010 ; Vol. 48, No. 5. pp. 851-858.
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