Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa

Irith Wiegand, Alexandra K. Marr, Elena B M Breidenstein, Kristen N. Schurek, Patrick Taylor, Robert E W Hancock

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Screening of the PA14 genomic transposon mutant library for resistance to ceftazidime, tobramycin, and ciprofloxacin led to the discovery of several mutants that appeared in more than one screen. Testing of the frequency of mutation to ciprofloxacin resistance revealed previously known mutator genes, including mutS and mutL, as well as mutators that have not yet been described for P. aeruginosa, including PA3958 and RadA (PA4609).

Original languageEnglish
Pages (from-to)3810-3813
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume52
Issue number10
DOIs
Publication statusPublished - Oct 2008
Externally publishedYes

Fingerprint

Ciprofloxacin
Pseudomonas aeruginosa
Anti-Bacterial Agents
Tobramycin
Ceftazidime
Mutation Rate
Genes

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

Cite this

Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa. / Wiegand, Irith; Marr, Alexandra K.; Breidenstein, Elena B M; Schurek, Kristen N.; Taylor, Patrick; Hancock, Robert E W.

In: Antimicrobial Agents and Chemotherapy, Vol. 52, No. 10, 10.2008, p. 3810-3813.

Research output: Contribution to journalArticle

Wiegand, Irith ; Marr, Alexandra K. ; Breidenstein, Elena B M ; Schurek, Kristen N. ; Taylor, Patrick ; Hancock, Robert E W. / Mutator genes giving rise to decreased antibiotic susceptibility in Pseudomonas aeruginosa. In: Antimicrobial Agents and Chemotherapy. 2008 ; Vol. 52, No. 10. pp. 3810-3813.
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