Mutant p53 exerts oncogenic effects through microRNAs and their target gene networks

Xiao Ling Li, Matthew F. Jones, Murugan Subramanian, Ashish Lal

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

MicroRNAs are potent regulators of gene expression and modulate multiple cellular processes including proliferation, differentiation and apoptosis. A number of microRNAs have been shown to be regulated by p53, the most frequently mutated gene in human cancer. It is has been demonstrated that some mutant p53 proteins not only lose tumor suppressor activity, but also acquire novel oncogenic functions that are independent of wild-type p53. In this review, we highlight recent evidences suggesting that some mutant p53 proteins regulate the expression of specific microRNAs to gain oncogenic functions and identify a gene network regulated by the microRNAs downstream of mutant p53.

Original languageEnglish
Pages (from-to)2610-2615
Number of pages6
JournalFEBS Letters
Volume588
Issue number16
DOIs
Publication statusPublished - 19 Aug 2014

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Keywords

  • Cancer
  • Gain-of-function
  • Invasion
  • Let-7
  • Metastasis
  • Mutant p53
  • miR-128-2
  • miR-130b
  • miR-155
  • miR-205
  • miR-223
  • miR-27a
  • miRNA
  • microRNA

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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