Muscle LIM Protein: Master regulator of cardiac and skeletal muscle functions

Elizabeth Vafiadaki, Demetrios A. Arvanitis, Despina Sanoudou

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Muscle LIM Protein (MLP) has emerged as a key regulator of striated muscle physiology and pathophysiology. Mutations in cysteine and glycine-rich protein 3 (. CSRP3), the gene encoding MLP, are causative of human cardiomyopathies, whereas altered expression patterns are observed in human failing heart and skeletal myopathies. In vitro and in vivo evidences reveal a complex and diverse functional role of MLP in striated muscle, which is determined by its multiple interacting partners and subcellular distribution. Experimental evidence suggests that MLP is implicated in both myogenic differentiation and myocyte cytoarchitecture, although the full spectrum of its intracellular roles still unfolds.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalGene
Volume566
Issue number1
DOIs
Publication statusPublished - 15 Jul 2015
Externally publishedYes

    Fingerprint

Keywords

  • Cardiomyopathies
  • Differentiation
  • Heart failure
  • MLP
  • Muscle structure
  • Sarcomere
  • Skeletal myopathies

ASJC Scopus subject areas

  • Genetics

Cite this