Murine segmental duplications are hot spots for chromosome and gene evolution

Lluís Armengol, Tomàs Marquès-Bonet, Joseph Cheung, Razi Khaja, Juan R. González, Stephen W. Scherer, Arcadi Navarro, Xavier P. Estivill

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Mouse and rat genomic sequences permit us to obtain a global view of evolutionary rearrangements that have occurred between the two species and to define hallmarks that might underlie these events. We present a comparative study of the sequence assemblies of mouse and rat genomes and report an enrichment of rodent-specific segmental duplications in regions where synteny is not preserved. We show that segmental duplications present higher rates of molecular evolution and that genes in rearranged regions have evolved faster than those located elsewhere. Previous studies have shown that synteny breakpoints between the mouse and the human genomes are enriched in human segmental duplications, suggesting a causative connection between such structures and evolutionary rearrangements. Our work provides further evidence to support the role of segmental duplications in chromosomal rearrangements in the evolution of the architecture of mammalian chromosomes and in the speciation processes that separate the mouse and the rat.

Original languageEnglish
Pages (from-to)692-700
Number of pages9
JournalGenomics
Volume86
Issue number6
DOIs
Publication statusPublished - Dec 2005
Externally publishedYes

Fingerprint

Genomic Segmental Duplications
Chromosomes
Synteny
Genes
Mammalian Chromosomes
Molecular Evolution
Human Genome
Rodentia
Genome

Keywords

  • Chromosomal evolution
  • Evolutionary breakpoints
  • Molecular evolution
  • Mouse genome
  • Rat genome
  • Segmental duplications
  • Synteny breakpoints

ASJC Scopus subject areas

  • Genetics

Cite this

Armengol, L., Marquès-Bonet, T., Cheung, J., Khaja, R., González, J. R., Scherer, S. W., ... Estivill, X. P. (2005). Murine segmental duplications are hot spots for chromosome and gene evolution. Genomics, 86(6), 692-700. https://doi.org/10.1016/j.ygeno.2005.08.008

Murine segmental duplications are hot spots for chromosome and gene evolution. / Armengol, Lluís; Marquès-Bonet, Tomàs; Cheung, Joseph; Khaja, Razi; González, Juan R.; Scherer, Stephen W.; Navarro, Arcadi; Estivill, Xavier P.

In: Genomics, Vol. 86, No. 6, 12.2005, p. 692-700.

Research output: Contribution to journalArticle

Armengol, L, Marquès-Bonet, T, Cheung, J, Khaja, R, González, JR, Scherer, SW, Navarro, A & Estivill, XP 2005, 'Murine segmental duplications are hot spots for chromosome and gene evolution', Genomics, vol. 86, no. 6, pp. 692-700. https://doi.org/10.1016/j.ygeno.2005.08.008
Armengol L, Marquès-Bonet T, Cheung J, Khaja R, González JR, Scherer SW et al. Murine segmental duplications are hot spots for chromosome and gene evolution. Genomics. 2005 Dec;86(6):692-700. https://doi.org/10.1016/j.ygeno.2005.08.008
Armengol, Lluís ; Marquès-Bonet, Tomàs ; Cheung, Joseph ; Khaja, Razi ; González, Juan R. ; Scherer, Stephen W. ; Navarro, Arcadi ; Estivill, Xavier P. / Murine segmental duplications are hot spots for chromosome and gene evolution. In: Genomics. 2005 ; Vol. 86, No. 6. pp. 692-700.
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