Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population

Michella Ghassibe-Sabbagh, Mary Deeb, Angelique K. Salloum, Francis Mouzaya, Marc Haber, Yaser Al-Sarraj, Youssef Chami, Yasmine Akle, Kamal Hirbli, Rita Nemr, Rechdi Ahdab, Daniel E. Platt, Antoine B. Abchee, Hatem El-Shanti, Pierre A. Zalloua

Research output: Contribution to journalArticle

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Abstract

Background: The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, in addition to 7,292 already available, were studied to investigate the prevalence of diabetes, prediabetes and their associated risk factors. Methods. Participants had fasting blood sugar and glycohemoglobin tests in addition to a lipid profile. Clinical and demographic information were obtained from a detailed questionnaire. The relationship between T2DM, its risk factors, and its complications were tested. Comparisons of these risk factors among diabetics, healthy, and coronary artery disease (CAD) patients were performed. Results: The prevalence of T2DM significantly increased with increasing BMI (p < 0.0001). Exercise activity level negatively correlated with the disease (p = 0.002), whereas the prevalence of T2DM (p < 0.0001) and CAD family history (p = 0.006) positively correlated with the affection status. The mean levels of triglycerides and LDL-C were significantly higher in diabetics (1.87; 1.35) compared to individuals with prediabetes (1.63; 1.26) and unaffected controls (1.49; 1.19). People with T2DM showed a significant decrease in HDL-C levels. A strong correlation of overall hyperlipidemia with the diabetes affection status was shown (p < 0.0001). Other comorbid factors such as hypertension (p < 0.0001) and self-reported obesity (p < 0.0001) were highly associated with T2DM and prediabetes. Reproductive health of women showed a strong correlation between giving birth to a baby with a high weight and the occurrence of T2DM and prediabetes later in life (p < 0.0001). Retinopathy and peripheral neuropathy were significantly correlated with diabetes and prediabetes (p < 0.0001). Conclusions: The present study shows an alarming prevalence of diabetes and prediabetes in the studied subgroups representative of the Lebanese population.

Original languageEnglish
Article number89
JournalDiabetology and Metabolic Syndrome
Volume6
Issue number1
DOIs
Publication statusPublished - 21 Aug 2014
Externally publishedYes

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Prediabetic State
Type 2 Diabetes Mellitus
Multivariate Analysis
Population
Coronary Artery Disease
Lebanon
Reproductive Health
Peripheral Nervous System Diseases
Hyperlipidemias
Blood Glucose
Fasting
Obesity
Demography
Parturition
Exercise
Hypertension
Lipids
Weights and Measures

Keywords

  • Coronary artery disease
  • Hyperlipidemia
  • Lebanon
  • Prediabetes
  • Risk factors
  • Type 2 diabetes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population. / Ghassibe-Sabbagh, Michella; Deeb, Mary; Salloum, Angelique K.; Mouzaya, Francis; Haber, Marc; Al-Sarraj, Yaser; Chami, Youssef; Akle, Yasmine; Hirbli, Kamal; Nemr, Rita; Ahdab, Rechdi; Platt, Daniel E.; Abchee, Antoine B.; El-Shanti, Hatem; Zalloua, Pierre A.

In: Diabetology and Metabolic Syndrome, Vol. 6, No. 1, 89, 21.08.2014.

Research output: Contribution to journalArticle

Ghassibe-Sabbagh, M, Deeb, M, Salloum, AK, Mouzaya, F, Haber, M, Al-Sarraj, Y, Chami, Y, Akle, Y, Hirbli, K, Nemr, R, Ahdab, R, Platt, DE, Abchee, AB, El-Shanti, H & Zalloua, PA 2014, 'Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population', Diabetology and Metabolic Syndrome, vol. 6, no. 1, 89. https://doi.org/10.1186/1758-5996-6-89
Ghassibe-Sabbagh, Michella ; Deeb, Mary ; Salloum, Angelique K. ; Mouzaya, Francis ; Haber, Marc ; Al-Sarraj, Yaser ; Chami, Youssef ; Akle, Yasmine ; Hirbli, Kamal ; Nemr, Rita ; Ahdab, Rechdi ; Platt, Daniel E. ; Abchee, Antoine B. ; El-Shanti, Hatem ; Zalloua, Pierre A. / Multivariate epidemiologic analysis of type 2 diabetes mellitus risks in the Lebanese population. In: Diabetology and Metabolic Syndrome. 2014 ; Vol. 6, No. 1.
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AU - Mouzaya, Francis

AU - Haber, Marc

AU - Al-Sarraj, Yaser

AU - Chami, Youssef

AU - Akle, Yasmine

AU - Hirbli, Kamal

AU - Nemr, Rita

AU - Ahdab, Rechdi

AU - Platt, Daniel E.

AU - Abchee, Antoine B.

AU - El-Shanti, Hatem

AU - Zalloua, Pierre A.

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N2 - Background: The burden of diabetes in Lebanon requires well-targeted interventions for screening type 2 diabetes mellitus (T2DM) and prediabetes and prevention of risk factors. Newly recruited 998 Lebanese individuals, in addition to 7,292 already available, were studied to investigate the prevalence of diabetes, prediabetes and their associated risk factors. Methods. Participants had fasting blood sugar and glycohemoglobin tests in addition to a lipid profile. Clinical and demographic information were obtained from a detailed questionnaire. The relationship between T2DM, its risk factors, and its complications were tested. Comparisons of these risk factors among diabetics, healthy, and coronary artery disease (CAD) patients were performed. Results: The prevalence of T2DM significantly increased with increasing BMI (p < 0.0001). Exercise activity level negatively correlated with the disease (p = 0.002), whereas the prevalence of T2DM (p < 0.0001) and CAD family history (p = 0.006) positively correlated with the affection status. The mean levels of triglycerides and LDL-C were significantly higher in diabetics (1.87; 1.35) compared to individuals with prediabetes (1.63; 1.26) and unaffected controls (1.49; 1.19). People with T2DM showed a significant decrease in HDL-C levels. A strong correlation of overall hyperlipidemia with the diabetes affection status was shown (p < 0.0001). Other comorbid factors such as hypertension (p < 0.0001) and self-reported obesity (p < 0.0001) were highly associated with T2DM and prediabetes. Reproductive health of women showed a strong correlation between giving birth to a baby with a high weight and the occurrence of T2DM and prediabetes later in life (p < 0.0001). Retinopathy and peripheral neuropathy were significantly correlated with diabetes and prediabetes (p < 0.0001). Conclusions: The present study shows an alarming prevalence of diabetes and prediabetes in the studied subgroups representative of the Lebanese population.

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