Multigenic human hypertension: Evidence for subtypes and hope for haplotypes

R. R. Williams, Steven Hunt, S. J. Hasstedt, P. N. Hopkins, L. L. Wu, T. D. Berry, B. M. Stults, G. K. Barlow, M. C. Schumacher, R. P. Lifton, J. M. Lalouel

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Hypertension that occurs before the age of 60 years is strongly aggregated in families, mostly due to genetic factors with weaker contributions from a shared family environment. Hypertension is probably a heterogeneous collection of overlapping subsets of pathophysiological mechanisms, such as dyslipidemia, obesity, hyperinsulinemia and cation metabolism. Highly heritable traits such as sodium-lithium countertransport, urinary kallikrein excretion and a body fat pattern index show evidence of major gene segregation in families with hypertension. They are thought to be intermediate phenotypes in the chain of pathophysiological events leading from specific genes to the distant phenotype of hypertension. They provide evidence of measurable contribution from single gene traits to the susceptibility to hypertension. Genetic linkage studies have suggested that other specific loci (e.g. histocompatibility leukocyte antigen, blood group MN and the haptoglobin protein) contribute to the susceptibility to hypertension. DNA sequencing has shown a point mutation for lipoprotein lipase that conveys susceptibility to lipid abnormalities, and possibly also hypertension, as seen in families with dyslipidemic hypertension. Further application of these approaches, especially in families that include multiple siblings with hypertension, shows promise of a true understanding of how the combined effects of a few specific genes, the polygenic background and selected environmental factors can lead to essential hypertension. This understanding should foster better tailored and more effective approaches to the prevention, diagnosis and treatment of hypertension.

Original languageEnglish
JournalJournal of Hypertension
Volume8
Issue numberSUPPL. 7
DOIs
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Haplotypes
Hypertension
Genes
Phenotype
Tissue Kallikreins
Histocompatibility Antigens
Genetic Linkage
Haptoglobins
Lipoprotein Lipase
Hyperinsulinism
Blood Group Antigens
Dyslipidemias
HLA Antigens
DNA Sequence Analysis
Lithium
Point Mutation
Cations
Adipose Tissue
Obesity
Sodium

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Williams, R. R., Hunt, S., Hasstedt, S. J., Hopkins, P. N., Wu, L. L., Berry, T. D., ... Lalouel, J. M. (1990). Multigenic human hypertension: Evidence for subtypes and hope for haplotypes. Journal of Hypertension, 8(SUPPL. 7). https://doi.org/10.1097/00004872-199006002-00007

Multigenic human hypertension : Evidence for subtypes and hope for haplotypes. / Williams, R. R.; Hunt, Steven; Hasstedt, S. J.; Hopkins, P. N.; Wu, L. L.; Berry, T. D.; Stults, B. M.; Barlow, G. K.; Schumacher, M. C.; Lifton, R. P.; Lalouel, J. M.

In: Journal of Hypertension, Vol. 8, No. SUPPL. 7, 1990.

Research output: Contribution to journalArticle

Williams, RR, Hunt, S, Hasstedt, SJ, Hopkins, PN, Wu, LL, Berry, TD, Stults, BM, Barlow, GK, Schumacher, MC, Lifton, RP & Lalouel, JM 1990, 'Multigenic human hypertension: Evidence for subtypes and hope for haplotypes', Journal of Hypertension, vol. 8, no. SUPPL. 7. https://doi.org/10.1097/00004872-199006002-00007
Williams, R. R. ; Hunt, Steven ; Hasstedt, S. J. ; Hopkins, P. N. ; Wu, L. L. ; Berry, T. D. ; Stults, B. M. ; Barlow, G. K. ; Schumacher, M. C. ; Lifton, R. P. ; Lalouel, J. M. / Multigenic human hypertension : Evidence for subtypes and hope for haplotypes. In: Journal of Hypertension. 1990 ; Vol. 8, No. SUPPL. 7.
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