Multi-parametric (mp) MRI for the diagnosis of abdominal wall desmoid tumors

Maneesh Khanna, Subramaniyan Ramanathan, Aalaa Salaheldin Kambal, Mohammed Al-Berawi, Santosh K. Yadav, Devendra Kumar, Nicola Schieda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction Desmoid tumors are benign myofibroblastic neoplasms, originating from the muscle aponeurosis and classified as deep fibromatoses. The aim of this study was to evaluate the utility of multi-parametric (mp)-MRI for the diagnosis of abdominal wall desmoid tumor (awdt). Material and methods This Institutional review board approved retrospective study compared 10 patients (mean age ± SD; 38.2 ± 13 years; 9 females and 1 male) with awdt to 14 subjects (mean age ± SD; 45.6 ± 14.7 years; 9 females and 5 males) with non-desmoid abdominal wall tumors (ndawt). All included subjects underwent mp-MRI, which included conventional, diffusion weighted and dynamic contrast-enhanced (DCE) MRI. Two blinded experienced fellowship trained radiologists (MK and SR) evaluated each lesion characteristics qualitatively and quantitatively which included margin, homogeneity, T2W/T1W signal intensity (SI), T2 dark strands, and fascial tail together with measurements of apparent diffusion coefficient (ADC) and semi-quantitative DCE analysis. Inter-observer agreement was assessed using Cohen's kappa and data were compared between groups using independent sample t-tests and Chi-square tests. Results No significant differences in age or gender appeared between groups. On qualitative analysis, T2 dark strands were identified in 90% by both radiologist (K = 0.82) of awdt, while fascial tail was identified in 70% by radiologist 1 and 80% by second radiologist (k = 0.91) of awdt; however no other lesions showed these findings. Other subjective imaging findings did not significantly differ between groups with moderate-to-strong agreements (k = 0.7–1.0). On quantitative measurements, diffusion imaging awdt lesions showed higher mean ADC value compared to other lesions, although it did not reached at the level of significance. While on DCE MRI, all awdt lesions showed type 1 (progressive) DCE curve, however no significant difference was observed between groups. Conclusions T2 dark strands and fascial tail are characteristic features of awdt, whereas other subjective/qualitative findings are not useful. Quantitative findings such as ADC measurements and DCE curve analysis may have additional value to differentiate awdt from ndawt, but will require further analysis.

Original languageEnglish
Pages (from-to)103-110
Number of pages8
JournalEuropean Journal of Radiology
Volume92
DOIs
Publication statusPublished - 1 Jul 2017
Externally publishedYes

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Aggressive Fibromatosis
Abdominal Wall
Neoplasms
Fibroma
Research Ethics Committees
Chi-Square Distribution

Keywords

  • Abdominal wall desmoid tumor
  • Diffusion weighted imaging
  • Dynamic contrast enhancement
  • MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Khanna, M., Ramanathan, S., Kambal, A. S., Al-Berawi, M., Yadav, S. K., Kumar, D., & Schieda, N. (2017). Multi-parametric (mp) MRI for the diagnosis of abdominal wall desmoid tumors. European Journal of Radiology, 92, 103-110. https://doi.org/10.1016/j.ejrad.2017.04.010

Multi-parametric (mp) MRI for the diagnosis of abdominal wall desmoid tumors. / Khanna, Maneesh; Ramanathan, Subramaniyan; Kambal, Aalaa Salaheldin; Al-Berawi, Mohammed; Yadav, Santosh K.; Kumar, Devendra; Schieda, Nicola.

In: European Journal of Radiology, Vol. 92, 01.07.2017, p. 103-110.

Research output: Contribution to journalArticle

Khanna, M, Ramanathan, S, Kambal, AS, Al-Berawi, M, Yadav, SK, Kumar, D & Schieda, N 2017, 'Multi-parametric (mp) MRI for the diagnosis of abdominal wall desmoid tumors', European Journal of Radiology, vol. 92, pp. 103-110. https://doi.org/10.1016/j.ejrad.2017.04.010
Khanna, Maneesh ; Ramanathan, Subramaniyan ; Kambal, Aalaa Salaheldin ; Al-Berawi, Mohammed ; Yadav, Santosh K. ; Kumar, Devendra ; Schieda, Nicola. / Multi-parametric (mp) MRI for the diagnosis of abdominal wall desmoid tumors. In: European Journal of Radiology. 2017 ; Vol. 92. pp. 103-110.
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abstract = "Introduction Desmoid tumors are benign myofibroblastic neoplasms, originating from the muscle aponeurosis and classified as deep fibromatoses. The aim of this study was to evaluate the utility of multi-parametric (mp)-MRI for the diagnosis of abdominal wall desmoid tumor (awdt). Material and methods This Institutional review board approved retrospective study compared 10 patients (mean age ± SD; 38.2 ± 13 years; 9 females and 1 male) with awdt to 14 subjects (mean age ± SD; 45.6 ± 14.7 years; 9 females and 5 males) with non-desmoid abdominal wall tumors (ndawt). All included subjects underwent mp-MRI, which included conventional, diffusion weighted and dynamic contrast-enhanced (DCE) MRI. Two blinded experienced fellowship trained radiologists (MK and SR) evaluated each lesion characteristics qualitatively and quantitatively which included margin, homogeneity, T2W/T1W signal intensity (SI), T2 dark strands, and fascial tail together with measurements of apparent diffusion coefficient (ADC) and semi-quantitative DCE analysis. Inter-observer agreement was assessed using Cohen's kappa and data were compared between groups using independent sample t-tests and Chi-square tests. Results No significant differences in age or gender appeared between groups. On qualitative analysis, T2 dark strands were identified in 90{\%} by both radiologist (K = 0.82) of awdt, while fascial tail was identified in 70{\%} by radiologist 1 and 80{\%} by second radiologist (k = 0.91) of awdt; however no other lesions showed these findings. Other subjective imaging findings did not significantly differ between groups with moderate-to-strong agreements (k = 0.7–1.0). On quantitative measurements, diffusion imaging awdt lesions showed higher mean ADC value compared to other lesions, although it did not reached at the level of significance. While on DCE MRI, all awdt lesions showed type 1 (progressive) DCE curve, however no significant difference was observed between groups. Conclusions T2 dark strands and fascial tail are characteristic features of awdt, whereas other subjective/qualitative findings are not useful. Quantitative findings such as ADC measurements and DCE curve analysis may have additional value to differentiate awdt from ndawt, but will require further analysis.",
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N2 - Introduction Desmoid tumors are benign myofibroblastic neoplasms, originating from the muscle aponeurosis and classified as deep fibromatoses. The aim of this study was to evaluate the utility of multi-parametric (mp)-MRI for the diagnosis of abdominal wall desmoid tumor (awdt). Material and methods This Institutional review board approved retrospective study compared 10 patients (mean age ± SD; 38.2 ± 13 years; 9 females and 1 male) with awdt to 14 subjects (mean age ± SD; 45.6 ± 14.7 years; 9 females and 5 males) with non-desmoid abdominal wall tumors (ndawt). All included subjects underwent mp-MRI, which included conventional, diffusion weighted and dynamic contrast-enhanced (DCE) MRI. Two blinded experienced fellowship trained radiologists (MK and SR) evaluated each lesion characteristics qualitatively and quantitatively which included margin, homogeneity, T2W/T1W signal intensity (SI), T2 dark strands, and fascial tail together with measurements of apparent diffusion coefficient (ADC) and semi-quantitative DCE analysis. Inter-observer agreement was assessed using Cohen's kappa and data were compared between groups using independent sample t-tests and Chi-square tests. Results No significant differences in age or gender appeared between groups. On qualitative analysis, T2 dark strands were identified in 90% by both radiologist (K = 0.82) of awdt, while fascial tail was identified in 70% by radiologist 1 and 80% by second radiologist (k = 0.91) of awdt; however no other lesions showed these findings. Other subjective imaging findings did not significantly differ between groups with moderate-to-strong agreements (k = 0.7–1.0). On quantitative measurements, diffusion imaging awdt lesions showed higher mean ADC value compared to other lesions, although it did not reached at the level of significance. While on DCE MRI, all awdt lesions showed type 1 (progressive) DCE curve, however no significant difference was observed between groups. Conclusions T2 dark strands and fascial tail are characteristic features of awdt, whereas other subjective/qualitative findings are not useful. Quantitative findings such as ADC measurements and DCE curve analysis may have additional value to differentiate awdt from ndawt, but will require further analysis.

AB - Introduction Desmoid tumors are benign myofibroblastic neoplasms, originating from the muscle aponeurosis and classified as deep fibromatoses. The aim of this study was to evaluate the utility of multi-parametric (mp)-MRI for the diagnosis of abdominal wall desmoid tumor (awdt). Material and methods This Institutional review board approved retrospective study compared 10 patients (mean age ± SD; 38.2 ± 13 years; 9 females and 1 male) with awdt to 14 subjects (mean age ± SD; 45.6 ± 14.7 years; 9 females and 5 males) with non-desmoid abdominal wall tumors (ndawt). All included subjects underwent mp-MRI, which included conventional, diffusion weighted and dynamic contrast-enhanced (DCE) MRI. Two blinded experienced fellowship trained radiologists (MK and SR) evaluated each lesion characteristics qualitatively and quantitatively which included margin, homogeneity, T2W/T1W signal intensity (SI), T2 dark strands, and fascial tail together with measurements of apparent diffusion coefficient (ADC) and semi-quantitative DCE analysis. Inter-observer agreement was assessed using Cohen's kappa and data were compared between groups using independent sample t-tests and Chi-square tests. Results No significant differences in age or gender appeared between groups. On qualitative analysis, T2 dark strands were identified in 90% by both radiologist (K = 0.82) of awdt, while fascial tail was identified in 70% by radiologist 1 and 80% by second radiologist (k = 0.91) of awdt; however no other lesions showed these findings. Other subjective imaging findings did not significantly differ between groups with moderate-to-strong agreements (k = 0.7–1.0). On quantitative measurements, diffusion imaging awdt lesions showed higher mean ADC value compared to other lesions, although it did not reached at the level of significance. While on DCE MRI, all awdt lesions showed type 1 (progressive) DCE curve, however no significant difference was observed between groups. Conclusions T2 dark strands and fascial tail are characteristic features of awdt, whereas other subjective/qualitative findings are not useful. Quantitative findings such as ADC measurements and DCE curve analysis may have additional value to differentiate awdt from ndawt, but will require further analysis.

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