Multi-center evaluation of post-operative morbidity and mortality after optimal cytoreductive surgery for advanced ovarian cancer

Arash Rafii, Eberhard Stoeckle, Mehdi Jean-Laurent, Gwenael Ferron, Philippe Morice, Gilles Houvenaeghel, Fabrice Lecuru, Eric Leblanc, Denis Querleu

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Purpose: While optimal cytoreduction is the standard of care for advanced ovarian cancer, the related post-operative morbidity has not been clearly documented outside pioneering centers. Indeed most of the studies are monocentric with inclusions over several years inducing heterogeneity in techniques and goals of surgery. We assessed the morbidity of optimal cytoreduction surgery for advanced ovarian cancer within a short inclusion period in 6 referral centers dedicated to achieve complete cytoreduction. Patients and Methods: The 30 last optimal debulking surgeries of 6 cancer centers were included. Inclusion criteria included: stage IIIc- IV ovarian cancer and optimal surgery performed at the site of inclusion. All post-operative complications within 30 days of surgery were recorded and graded using the Memorial secondary events grading system. Student-t, Chi2 and non-parametric statistical tests were performed. Results: 180 patients were included. There was no demographic differences between the centers. 63 patients underwent surgery including intestinal resections (58 recto-sigmoid resection), 24 diaphragmatic resections, 17 splenectomies. 61 patients presented complications; One patient died post-operatively. Major (grade 3-5) complications requiring subsequent surgeries occurred in 21 patients (11.5%). 76% of patients with a major complication had undergone an ultraradical surgery (P = 0.004). Conclusion: While ultraradical surgery may result in complete resection of peritoneal disease in advanced ovarian cancer, the associated complication rate is not negligible. Patients should be carefully evaluated and the timing of their surgery optimized in order to avoid major complications.

Original languageEnglish
Article numbere39415
JournalPLoS One
Volume7
Issue number7
DOIs
Publication statusPublished - 23 Jul 2012

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ovarian neoplasms
Ovarian Neoplasms
Surgery
morbidity
surgery
Morbidity
Mortality
resection
Peritoneal Diseases
postoperative complications
Sigmoid Colon
Splenectomy
Standard of Care
Statistical tests
Ambulatory Surgical Procedures
Referral and Consultation
students
Demography
statistical analysis
demographic statistics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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Multi-center evaluation of post-operative morbidity and mortality after optimal cytoreductive surgery for advanced ovarian cancer. / Rafii, Arash; Stoeckle, Eberhard; Jean-Laurent, Mehdi; Ferron, Gwenael; Morice, Philippe; Houvenaeghel, Gilles; Lecuru, Fabrice; Leblanc, Eric; Querleu, Denis.

In: PLoS One, Vol. 7, No. 7, e39415, 23.07.2012.

Research output: Contribution to journalArticle

Rafii, A, Stoeckle, E, Jean-Laurent, M, Ferron, G, Morice, P, Houvenaeghel, G, Lecuru, F, Leblanc, E & Querleu, D 2012, 'Multi-center evaluation of post-operative morbidity and mortality after optimal cytoreductive surgery for advanced ovarian cancer', PLoS One, vol. 7, no. 7, e39415. https://doi.org/10.1371/journal.pone.0039415
Rafii, Arash ; Stoeckle, Eberhard ; Jean-Laurent, Mehdi ; Ferron, Gwenael ; Morice, Philippe ; Houvenaeghel, Gilles ; Lecuru, Fabrice ; Leblanc, Eric ; Querleu, Denis. / Multi-center evaluation of post-operative morbidity and mortality after optimal cytoreductive surgery for advanced ovarian cancer. In: PLoS One. 2012 ; Vol. 7, No. 7.
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