MRI contrast agent delivery using spore capsules

Controlled release in blood plasma

Mark Lorch, Matthew J. Thomasson, Alberto Diego-Taboada, Sylvain Barrier, Stephen Atkin, Grahame MacKenzie, Stephen J. Archibald

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(iii) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.

Original languageEnglish
Pages (from-to)6442-6444
Number of pages3
JournalChemical Communications
Issue number42
DOIs
Publication statusPublished - 2009
Externally publishedYes

Fingerprint

gadodiamide
Gadolinium
Spores
Magnetic resonance imaging
Contrast Media
Capsules
Blood
Plasmas
Coatings
Molecules
Digestion
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S., MacKenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: Controlled release in blood plasma. Chemical Communications, (42), 6442-6444. https://doi.org/10.1039/b909551a

MRI contrast agent delivery using spore capsules : Controlled release in blood plasma. / Lorch, Mark; Thomasson, Matthew J.; Diego-Taboada, Alberto; Barrier, Sylvain; Atkin, Stephen; MacKenzie, Grahame; Archibald, Stephen J.

In: Chemical Communications, No. 42, 2009, p. 6442-6444.

Research output: Contribution to journalArticle

Lorch, M, Thomasson, MJ, Diego-Taboada, A, Barrier, S, Atkin, S, MacKenzie, G & Archibald, SJ 2009, 'MRI contrast agent delivery using spore capsules: Controlled release in blood plasma', Chemical Communications, no. 42, pp. 6442-6444. https://doi.org/10.1039/b909551a
Lorch, Mark ; Thomasson, Matthew J. ; Diego-Taboada, Alberto ; Barrier, Sylvain ; Atkin, Stephen ; MacKenzie, Grahame ; Archibald, Stephen J. / MRI contrast agent delivery using spore capsules : Controlled release in blood plasma. In: Chemical Communications. 2009 ; No. 42. pp. 6442-6444.
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