MRI contrast agent delivery using spore capsules: Controlled release in blood plasma

Mark Lorch, Matthew J. Thomasson, Alberto Diego-Taboada, Sylvain Barrier, Stephen Atkin, Grahame MacKenzie, Stephen J. Archibald

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(iii) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.

Original languageEnglish
Pages (from-to)6442-6444
Number of pages3
JournalChemical Communications
Issue number42
DOIs
Publication statusPublished - 2009
Externally publishedYes

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ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Lorch, M., Thomasson, M. J., Diego-Taboada, A., Barrier, S., Atkin, S., MacKenzie, G., & Archibald, S. J. (2009). MRI contrast agent delivery using spore capsules: Controlled release in blood plasma. Chemical Communications, (42), 6442-6444. https://doi.org/10.1039/b909551a