Molecule-responsive block copolymer micelles

Yoshihiro Ishihara, Hassan S. Bazzi, Violeta Toader, François Godin, Hanadi F. Sleiman

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Ring-opening metathesis polymerization was used to generate an ABC triblock copolymer, containing complementary diamidopyridine (DAP) and thymine (THY) outer blocks, which assembles into spherical aggregates held together by DAPTHY noncovalent interactions. Addition of THY-containing small guest molecules results in complete opening and deaggregation of the block copolymer micelle. This molecular recognition and macroscopic response showshigh selectivity to the guest structure, and tolerates only a small amount of conformational mobility in the THY guest. On the other hand, addition of a small DAP-containing guest does not break the aggregates, but instead, results in new micelles which show a different selectivity profile from the parent morphology. We have examined the effect of a number of structural features in the block copolymers, on both the extent and selectivity of their macroscopic response to guests (that is, opening of the micelle). This study has resulted in a set of structural guidelines, which help in the design of effective molecule-responsive micelles for applications in selective drug delivery, sensing, and surface patterning.

Original languageEnglish
Pages (from-to)4560-4570
Number of pages11
JournalChemistry - A European Journal
Volume13
Issue number16
DOIs
Publication statusPublished - 2007

Fingerprint

Micelles
Block copolymers
Thymine
Molecules
Molecular recognition
Ring opening polymerization
Drug delivery
Polymerization
Guidelines
Pharmaceutical Preparations
diamidopyridine

Keywords

  • Block copolymers
  • Host-guest systems
  • Micelles
  • Molecular recognition
  • Self-assembly

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Ishihara, Y., Bazzi, H. S., Toader, V., Godin, F., & Sleiman, H. F. (2007). Molecule-responsive block copolymer micelles. Chemistry - A European Journal, 13(16), 4560-4570. https://doi.org/10.1002/chem.200601423

Molecule-responsive block copolymer micelles. / Ishihara, Yoshihiro; Bazzi, Hassan S.; Toader, Violeta; Godin, François; Sleiman, Hanadi F.

In: Chemistry - A European Journal, Vol. 13, No. 16, 2007, p. 4560-4570.

Research output: Contribution to journalArticle

Ishihara, Y, Bazzi, HS, Toader, V, Godin, F & Sleiman, HF 2007, 'Molecule-responsive block copolymer micelles', Chemistry - A European Journal, vol. 13, no. 16, pp. 4560-4570. https://doi.org/10.1002/chem.200601423
Ishihara, Yoshihiro ; Bazzi, Hassan S. ; Toader, Violeta ; Godin, François ; Sleiman, Hanadi F. / Molecule-responsive block copolymer micelles. In: Chemistry - A European Journal. 2007 ; Vol. 13, No. 16. pp. 4560-4570.
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