Molecular signatures of antibody responses derived from a systems biology study of five human vaccines

Shuzhao Li, Nadine Rouphael, Sai Duraisingham, Sandra Romero-Steiner, Scott Presnell, Carl Davis, Daniel S. Schmidt, Scott E. Johnson, Andrea Milton, Gowrisankar Rajam, Sudhir Kasturi, George M. Carlone, Charlie Quinn, Damien J. Chaussabel, A. Karolina Palucka, Mark J. Mulligan, Rafi Ahmed, David S. Stephens, Helder I. Nakaya, Bali Pulendran

Research output: Contribution to journalArticle

Abstract

Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used to determine signatures that can be used to predict vaccine-induced immunity in humans, but whether there is a 'universal signature' that can be used to predict antibody responses to any vaccine is unknown. Here we did systems analyses of immune responses to the polysaccharide and conjugate vaccines against meningococcus in healthy adults, in the broader context of published studies of vaccines against yellow fever virus and influenza virus. To achieve this, we did a large-scale network integration of publicly available human blood transcriptomes and systems-scale databases in specific biological contexts and deduced a set of transcription modules in blood. Those modules revealed distinct transcriptional signatures of antibody responses to different classes of vaccines, which provided key insights into primary viral, protein recall and anti-polysaccharide responses. Our results elucidate the early transcriptional programs that orchestrate vaccine immunity in humans and demonstrate the power of integrative network modeling.

Original languageEnglish
Pages (from-to)195-204
Number of pages10
JournalNature Immunology
Volume15
Issue number2
DOIs
Publication statusPublished - Feb 2014
Externally publishedYes

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Systems Biology
Antibody Formation
Vaccines
Immunity
Polysaccharides
Yellow fever virus
Conjugate Vaccines
Neisseria meningitidis
Viral Proteins
Systems Analysis
Orthomyxoviridae
Transcriptome
Databases
Antibodies

ASJC Scopus subject areas

  • Immunology

Cite this

Li, S., Rouphael, N., Duraisingham, S., Romero-Steiner, S., Presnell, S., Davis, C., ... Pulendran, B. (2014). Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. Nature Immunology, 15(2), 195-204. https://doi.org/10.1038/ni.2789

Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. / Li, Shuzhao; Rouphael, Nadine; Duraisingham, Sai; Romero-Steiner, Sandra; Presnell, Scott; Davis, Carl; Schmidt, Daniel S.; Johnson, Scott E.; Milton, Andrea; Rajam, Gowrisankar; Kasturi, Sudhir; Carlone, George M.; Quinn, Charlie; Chaussabel, Damien J.; Palucka, A. Karolina; Mulligan, Mark J.; Ahmed, Rafi; Stephens, David S.; Nakaya, Helder I.; Pulendran, Bali.

In: Nature Immunology, Vol. 15, No. 2, 02.2014, p. 195-204.

Research output: Contribution to journalArticle

Li, S, Rouphael, N, Duraisingham, S, Romero-Steiner, S, Presnell, S, Davis, C, Schmidt, DS, Johnson, SE, Milton, A, Rajam, G, Kasturi, S, Carlone, GM, Quinn, C, Chaussabel, DJ, Palucka, AK, Mulligan, MJ, Ahmed, R, Stephens, DS, Nakaya, HI & Pulendran, B 2014, 'Molecular signatures of antibody responses derived from a systems biology study of five human vaccines', Nature Immunology, vol. 15, no. 2, pp. 195-204. https://doi.org/10.1038/ni.2789
Li S, Rouphael N, Duraisingham S, Romero-Steiner S, Presnell S, Davis C et al. Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. Nature Immunology. 2014 Feb;15(2):195-204. https://doi.org/10.1038/ni.2789
Li, Shuzhao ; Rouphael, Nadine ; Duraisingham, Sai ; Romero-Steiner, Sandra ; Presnell, Scott ; Davis, Carl ; Schmidt, Daniel S. ; Johnson, Scott E. ; Milton, Andrea ; Rajam, Gowrisankar ; Kasturi, Sudhir ; Carlone, George M. ; Quinn, Charlie ; Chaussabel, Damien J. ; Palucka, A. Karolina ; Mulligan, Mark J. ; Ahmed, Rafi ; Stephens, David S. ; Nakaya, Helder I. ; Pulendran, Bali. / Molecular signatures of antibody responses derived from a systems biology study of five human vaccines. In: Nature Immunology. 2014 ; Vol. 15, No. 2. pp. 195-204.
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