Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients

Maria Libera Ascierto, Michael O. Idowu, Yingdong Zhao, Hanif Khalak, Kyle K. Payne, Xiang Yang Wang, Catherine I. Dumur, Davide Bedognetti, Sara Tomei, Paolo A. Ascierto, Anil Shanker, Harry D. Bear, Ena Wang, Francesco M. Marincola, Andrea De Maria, Masoud H. Manjili

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.Methods: Here, we performed a retrospective pilot study to investigate whether the coordinate expression of molecular signature mostly associated with NK cells could be used to segregate breast cancer patients into relapse and relapse-free outcomes.Results: By analyzing primary breast cancer specimens derived from patients who experienced either 58-116 months (~5-9 years) relapse-free survival or developed tumor relapse within 9-76 months (~1-6 years) we found that the expression of molecules involved in activating signaling of NK cells and in NK cells: target interaction is increased in patients with favorable prognosis.Conclusions: The parameters identified in this study, together with the prognostic signature previously reported by our group, highlight the cooperation between the innate and adaptive immune components within the tumor microenvironment.

Original languageEnglish
Article number145
JournalJournal of Translational Medicine
Volume11
Issue number1
DOIs
Publication statusPublished - 12 Jun 2013
Externally publishedYes

Fingerprint

Natural Killer Cells
Tumors
Breast Neoplasms
Recurrence
Survival
Immune system
Genes
Chemical activation
Tissue
Molecules
Tumor Microenvironment
Cell Communication
Transcriptional Activation
Immune System
Retrospective Studies
Neoplasms

Keywords

  • Breast cancer prognosis
  • Innate immunity
  • Molecular markers
  • NK cells
  • Tumour microenvironment
  • Tumour relapse

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients. / Ascierto, Maria Libera; Idowu, Michael O.; Zhao, Yingdong; Khalak, Hanif; Payne, Kyle K.; Wang, Xiang Yang; Dumur, Catherine I.; Bedognetti, Davide; Tomei, Sara; Ascierto, Paolo A.; Shanker, Anil; Bear, Harry D.; Wang, Ena; Marincola, Francesco M.; De Maria, Andrea; Manjili, Masoud H.

In: Journal of Translational Medicine, Vol. 11, No. 1, 145, 12.06.2013.

Research output: Contribution to journalArticle

Ascierto, ML, Idowu, MO, Zhao, Y, Khalak, H, Payne, KK, Wang, XY, Dumur, CI, Bedognetti, D, Tomei, S, Ascierto, PA, Shanker, A, Bear, HD, Wang, E, Marincola, FM, De Maria, A & Manjili, MH 2013, 'Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients', Journal of Translational Medicine, vol. 11, no. 1, 145. https://doi.org/10.1186/1479-5876-11-145
Ascierto, Maria Libera ; Idowu, Michael O. ; Zhao, Yingdong ; Khalak, Hanif ; Payne, Kyle K. ; Wang, Xiang Yang ; Dumur, Catherine I. ; Bedognetti, Davide ; Tomei, Sara ; Ascierto, Paolo A. ; Shanker, Anil ; Bear, Harry D. ; Wang, Ena ; Marincola, Francesco M. ; De Maria, Andrea ; Manjili, Masoud H. / Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients. In: Journal of Translational Medicine. 2013 ; Vol. 11, No. 1.
@article{d879bbe867f94b99b32c3d56ce74fbc8,
title = "Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients",
abstract = "Background: Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.Methods: Here, we performed a retrospective pilot study to investigate whether the coordinate expression of molecular signature mostly associated with NK cells could be used to segregate breast cancer patients into relapse and relapse-free outcomes.Results: By analyzing primary breast cancer specimens derived from patients who experienced either 58-116 months (~5-9 years) relapse-free survival or developed tumor relapse within 9-76 months (~1-6 years) we found that the expression of molecules involved in activating signaling of NK cells and in NK cells: target interaction is increased in patients with favorable prognosis.Conclusions: The parameters identified in this study, together with the prognostic signature previously reported by our group, highlight the cooperation between the innate and adaptive immune components within the tumor microenvironment.",
keywords = "Breast cancer prognosis, Innate immunity, Molecular markers, NK cells, Tumour microenvironment, Tumour relapse",
author = "Ascierto, {Maria Libera} and Idowu, {Michael O.} and Yingdong Zhao and Hanif Khalak and Payne, {Kyle K.} and Wang, {Xiang Yang} and Dumur, {Catherine I.} and Davide Bedognetti and Sara Tomei and Ascierto, {Paolo A.} and Anil Shanker and Bear, {Harry D.} and Ena Wang and Marincola, {Francesco M.} and {De Maria}, Andrea and Manjili, {Masoud H.}",
year = "2013",
month = "6",
day = "12",
doi = "10.1186/1479-5876-11-145",
language = "English",
volume = "11",
journal = "Journal of Translational Medicine",
issn = "1479-5876",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients

AU - Ascierto, Maria Libera

AU - Idowu, Michael O.

AU - Zhao, Yingdong

AU - Khalak, Hanif

AU - Payne, Kyle K.

AU - Wang, Xiang Yang

AU - Dumur, Catherine I.

AU - Bedognetti, Davide

AU - Tomei, Sara

AU - Ascierto, Paolo A.

AU - Shanker, Anil

AU - Bear, Harry D.

AU - Wang, Ena

AU - Marincola, Francesco M.

AU - De Maria, Andrea

AU - Manjili, Masoud H.

PY - 2013/6/12

Y1 - 2013/6/12

N2 - Background: Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.Methods: Here, we performed a retrospective pilot study to investigate whether the coordinate expression of molecular signature mostly associated with NK cells could be used to segregate breast cancer patients into relapse and relapse-free outcomes.Results: By analyzing primary breast cancer specimens derived from patients who experienced either 58-116 months (~5-9 years) relapse-free survival or developed tumor relapse within 9-76 months (~1-6 years) we found that the expression of molecules involved in activating signaling of NK cells and in NK cells: target interaction is increased in patients with favorable prognosis.Conclusions: The parameters identified in this study, together with the prognostic signature previously reported by our group, highlight the cooperation between the innate and adaptive immune components within the tumor microenvironment.

AB - Background: Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.Methods: Here, we performed a retrospective pilot study to investigate whether the coordinate expression of molecular signature mostly associated with NK cells could be used to segregate breast cancer patients into relapse and relapse-free outcomes.Results: By analyzing primary breast cancer specimens derived from patients who experienced either 58-116 months (~5-9 years) relapse-free survival or developed tumor relapse within 9-76 months (~1-6 years) we found that the expression of molecules involved in activating signaling of NK cells and in NK cells: target interaction is increased in patients with favorable prognosis.Conclusions: The parameters identified in this study, together with the prognostic signature previously reported by our group, highlight the cooperation between the innate and adaptive immune components within the tumor microenvironment.

KW - Breast cancer prognosis

KW - Innate immunity

KW - Molecular markers

KW - NK cells

KW - Tumour microenvironment

KW - Tumour relapse

UR - http://www.scopus.com/inward/record.url?scp=84878817192&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878817192&partnerID=8YFLogxK

U2 - 10.1186/1479-5876-11-145

DO - 10.1186/1479-5876-11-145

M3 - Article

VL - 11

JO - Journal of Translational Medicine

JF - Journal of Translational Medicine

SN - 1479-5876

IS - 1

M1 - 145

ER -