Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T subsets

Ping Jin, Ena Wang, Maurizio Provenzano, Sara Deola, Silvia Selleri, Jiaqiang Ren, Sonia Voiculescu, David Stroncek, Monica C. Panelli, Francesco M. Marincola

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Abstract

Experimentally, interleukin-2 (IL-2) exerts complex immunological functions promoting the proliferation, survival and activation of T cells on one hand and inducing immune regulatory mechanisms on the other. This complexity results from a cross talk among immune cells which sways the effects of IL-2 according to the experimental or clinical condition tested. Recombinant IL-2 (rIL-2) stimulation of peripheral blood mononuclear cells (PBMC) from 47 donors of different genetic background induced generalized T cell activation and anti-apoptotic effects. Most effects were dependent upon interactions among immune cells. Specialized functions of CD4 and CD8 T cells were less dependent upon and often dampened by the presence of other PBMC populations. In particular, cytotoxic T cell effector function was variably affected with a component strictly dependent upon the direct stimulation of CD8 T cells in the absence of other PBMC. This observation may provide a roadmap for the interpretation of the discrepant biological activities of rIL-2 observed in distinct pathological conditions or treatment modalities.

Original languageEnglish
Article number26
JournalJournal of Translational Medicine
Volume4
DOIs
Publication statusPublished - 28 Jun 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Jin, P., Wang, E., Provenzano, M., Deola, S., Selleri, S., Ren, J., Voiculescu, S., Stroncek, D., Panelli, M. C., & Marincola, F. M. (2006). Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T subsets. Journal of Translational Medicine, 4, [26]. https://doi.org/10.1186/1479-5876-4-26