Postpneumonectomy compensatory lung growth refers to a phenomenon of rapid restoration of lung parenchyma following the resection of significant amounts of lung tissue. Whether this growth response represents a recapitulation of normal so-called pre- or postnatal developmental lung growth, and whether it represents a hypertrophic or hyperplastic response with addition of new alveoli, have been debated (1,2). Furthermore, although postpneumonectomy lung growth has been well characterized morphologically and physiologically in experimental models of several species of higher animals, its application to humans, both scientifically and clinically, is less clear (3,4). Nevertheless, with recent scientific advances allowing study of physiological mechanisms at the molecular level, new data have provided valuable clues to understanding the stimuli, genetic and cellular responses, and physiological adaption to lung growth following pneumonectomy. A number of genes, including specific transcription factors, have been identified as participants in lung morphogenesis and alveolarization (5-7). This chapter will review the historical studies defining the timing, pattern, and morphological response to pneumonectomy in animal models. It will then summarize the current understanding of postpneumonectomy compensation at the molecular level, including recent studies that have attempted to use modern techniques to manipulate the system to augment or inhibit lung growth.
|Title of host publication||Lung Development and Regeneration|
|Number of pages||27|
|Publication status||Published - 1 Jan 2004|
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